Origin and Evolution of Dengue Virus Type 3 in Brazil

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PLoSNTDs

PLoSNTDs

PLOS Neglected Tropical Diseases is the first open-access journal devoted to the world's most neglected tropical diseases (NTDs), such as elephantiasis, river blindness, leprosy, hookworm, schistosomiasis, and African sleeping sickness. Links to PLoSNTD content is shared via GHHub using the Creative Commons. http://www.plosntds.org/

by Josélio Maria Galvão de Araújo, Gonzalo Bello, Hector Romero, Rita Maria Ribeiro Nogueira The incidence of dengue fever and dengue hemorrhagic fever in Brazil experienced a significant increase since the emergence of dengue virus type-3 (DENV-3) at the early 2000s. Despite the major public health concerns, there have been very few studies of the molecular epidemiology and time-scale of this DENV lineage in Brazil. In this study, we investigated the origin and dispersion dynamics of DENV-3 genotype III in Brazil by examining a large number (n = 107) of E gene sequences sampled between 2001 and 2009 from diverse Brazilian regions. These Brazilian sequences were combined with 457 DENV-3 genotype III E gene sequences from 29 countries around the world. Our phylogenetic analysis reveals that there have been at least four introductions of the DENV-3 genotype III in Brazil, as signified by the presence of four phylogenetically distinct lineages

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Origin and Evolution of Dengue Virus Type 3 in Brazil