Intracellular Spread of Rabies Virus Is Reduced in the Paralytic Form of Canine Rabies Compared…

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PLoSNTDs

PLoSNTDs

PLOS Neglected Tropical Diseases is the first open-access journal devoted to the world's most neglected tropical diseases (NTDs), such as elephantiasis, river blindness, leprosy, hookworm, schistosomiasis, and African sleeping sickness. Links to PLoSNTD content is shared via GHHub using the Creative Commons. http://www.plosntds.org/

by Shanop Shuangshoti, Paul Scott Thorner, Chinachote Teerapakpinyo, Nisachol Thepa, Pornchai Phukpattaranont, Nirun Intarut, Boonlert Lumlertdacha, Veera Tepsumethanon, Thiravat Hemachudha Studies of the furious and paralytic forms of canine rabies at the early stage of disease have shown a more rapid viral colonization of the cerebral hemispheres in the furious form, as measured by viral antigen within neuronal cell bodies and viral RNA levels. Measurement of cellular processes separate from neuronal cell body provides a visual record of the spread of rabies virus which occurs across synapses. In this study, the amount of rabies viral antigen within cell processes was quantitatively assessed by image analysis in a cohort of naturally rabies infected non-vaccinated dogs (5 furious and 5 paralytic) that were sacrificed shortly after developing illness.

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Intracellular Spread of Rabies Virus Is Reduced in the Paralytic Form of Canine Rabies Compared…