Local selection in the presence of high levels of gene flow: Evidence of heterogeneous…

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PLoSNTDs

PLoSNTDs

PLOS Neglected Tropical Diseases is the first open-access journal devoted to the world's most neglected tropical diseases (NTDs), such as elephantiasis, river blindness, leprosy, hookworm, schistosomiasis, and African sleeping sickness. Links to PLoSNTD content is shared via GHHub using the Creative Commons. http://www.plosntds.org/

by Walter Fabricio Silva Martins, Craig Stephen Wilding, Keith Steen, Henry Mawejje, Tiago Rodrigues Antão, Martin James Donnelly Background Culex quinquefasciatus collected in Uganda, where no vector control interventions directly targeting this species have been conducted, was used as a model to determine if it is possible to detect heterogeneities in selection pressure driven by insecticide application targeting other insect species. Methodology/Principal findings Population genetic structure was assessed through microsatellite analysis, and the impact of insecticide pressure by genotyping two target-site mutations, Vgsc-1014F of the voltage-gated sodium channel target of pyrethroid and DDT insecticides, and Ace1-119S of the acetylcholinesterase gene, target of carbamate and organophosphate insecticides.

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Local selection in the presence of high levels of gene flow: Evidence of heterogeneous…