Long-term trends in mortality and AIDS-defining events after combination ART initiation among…

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PLoS Medicine

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by The European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group in EuroCoord , Ali Judd, Elizabeth Chappell, Anna Turkova, Sophie Le Coeur, Antoni Noguera-Julian, Tessa Goetghebuer, Katja Doerholt, Luisa Galli, Dasja Pajkrt, Laura Marques, Intira J. Collins, Diana M. Gibb, Maria Isabel González Tome, Marisa Navarro, Josiane Warszawski, Christoph Königs, Vana Spoulou, Filipa Prata, Elena Chiappini, Lars Naver, Carlo Giaquinto, Claire Thorne, Magdalena Marczynska, Liubov Okhonskaia, Klara Posfay-Barbe, Pradthana Ounchanum, Pornchai Techakunakorn, Galina Kiseleva, Ruslan Malyuta, Alla Volokha, Luminita Ene, Ruth Goodall Background Published estimates of mortality and progression to AIDS as children with HIV approach adulthood are limited. We describe rates and risk factors for death and AIDS-defining events in children and adolescents after initiation of combination antiretroviral therapy (cART) in 17 middle- and high-income countries, including some in Western and Central Europe (W&CE), Eastern Europe (Russia and Ukraine), and Thailand. Methods and findings Children with perinatal HIV aged <18 years initiating cART were followed until their 21st birthday, transfer to adult care, death, loss to follow-up, or last visit up until 31 December 2013

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Long-term trends in mortality and AIDS-defining events after combination ART initiation among…