Endogenous overexpression of an active phosphorylated form of DNA polymerase β under oxidative…

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PLoSNTDs

PLoSNTDs

PLOS Neglected Tropical Diseases is the first open-access journal devoted to the world's most neglected tropical diseases (NTDs), such as elephantiasis, river blindness, leprosy, hookworm, schistosomiasis, and African sleeping sickness. Links to PLoSNTD content is shared via GHHub using the Creative Commons. http://www.plosntds.org/

by Diego A. Rojas, Fabiola Urbina, Sandra Moreira-Ramos, Christian Castillo, Ulrike Kemmerling, Michel Lapier, Juan Diego Maya, Aldo Solari, Edio Maldonado Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative stress, leading to damage of several macromolecules such as DNA. There are many DNA repair pathways in the nucleus and mitochondria (kinetoplast), where specific protein complexes detect and eliminate damage to DNA

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Endogenous overexpression of an active phosphorylated form of DNA polymerase β under oxidative…