by Michael M. Mendelson, Riccardo E. Marioni, Roby Joehanes, Chunyu Liu, Åsa K. Hedman, Stella Aslibekyan, Ellen W. Demerath, Weihua Guan, Degui Zhi, Chen Yao, Tianxiao Huan, Christine Willinger, Brian Chen, Paul Courchesne, Michael Multhaup, Marguerite R
Author Archives: PLoS Medicine
by Fernando Abad-Franch, Elvira Zamora-Perea, Sérgio L. B. Luz Background Mosquito-borne viruses threaten public health worldwide. When the ratio of competent vectors to susceptible humans is low enough, the virus’s basic reproductive number (R0) falls below 1.0 (each case generating, on average, <1.0 additional case) and the infection fades out from the population. Conventional mosquito control tactics, however, seldom yield <i>R0 < 1.0.
by Gordon D. Schiff In a Perspective, Gordon Schiff discusses the importance of appropriately analyzing adverse event reports.
by Philippa Rees, Adrian Edwards, Colin Powell, Peter Hibbert, Huw Williams, Meredith Makeham, Ben Carter, Donna Luff, Gareth Parry, Anthony Avery, Aziz Sheikh, Liam Donaldson, Andrew Carson-Stevens Background The UK performs poorly relative to other economically developed countries on numerous indicators of care quality for children. The contribution of iatrogenic harm to these outcomes is unclear. As primary care is the first point of healthcare contact for most children, we sought to investigate the safety of care provided to children in this setting. Methods and Findings We undertook a mixed methods investigation of reports of primary care patient safety incidents involving sick children from England and Wales’ National Reporting and Learning System between 1 January 2005 and 1 December 2013.
by Richard M. Hoglund, Lesley Workman, Michael D. Edstein, Nguyen Xuan Thanh, Nguyen Ngoc Quang, Issaka Zongo, Jean Bosco Ouedraogo, Steffen Borrmann, Leah Mwai, Christian Nsanzabana, Ric N. Price, Prabin Dahal, Nancy C. Sambol, Sunil Parikh, Francois Nosten, Elizabeth A.
See the original article here: Reporting Items for Updated Clinical Guidelines: Checklist for the Reporting of Updated…
by Katherine A. Hoadley, Marni B. Siegel, Krishna L. Kanchi, Christopher A.
by Fabienne Krauer, Maurane Riesen, Ludovic Reveiz, Olufemi T. Oladapo, Ruth Martínez-Vega, Teegwendé V. Porgo, Anina Haefliger, Nathalie J. Broutet, Nicola Low, WHO Zika Causality Working Group Background The World Health Organization (WHO) stated in March 2016 that there was scientific consensus that the mosquito-borne Zika virus was a cause of the neurological disorder Guillain–Barré syndrome (GBS) and of microcephaly and other congenital brain abnormalities based on rapid evidence assessments. Decisions about causality require systematic assessment to guide public health actions
by Tess Harris, Sally M. Kerry, Elizabeth S. Limb, Christina R. Victor, Steve Iliffe, Michael Ussher, Peter H. Whincup, Ulf Ekelund, Julia Fox-Rushby, Cheryl Furness, Nana Anokye, Judith Ibison, Steve DeWilde, Lee David, Emma Howard, Rebecca Dale, Jaime Smith, Derek G.
by Aaron S. Kesselheim, Carolyn L. Treasure, Steven Joffe Aaron Kesselheim and colleagues examine orphan-designated drugs approved between 2009 and 2015 in the United States.
by Emily A. Kendall, Sourya Shrestha, Ted Cohen, Eric Nuermberger, Kelly E. Dooley, Lice Gonzalez-Angulo, Gavin J. Churchyard, Payam Nahid, Michael L. Rich, Cathy Bansbach, Thomas Forissier, Christian Lienhardt, David W.
by Maria Carolina Borges, Maria Laura Louzada, Thiago Hérick de Sá, Anthony A. Laverty, Diana C. Parra, Josefa Maria Fellegger Garzillo, Carlos Augusto Monteiro, Christopher Millett Christopher Millett and colleagues argue that artificially sweetened beverages should not be promoted as part of a healthy diet.
by Matthew Herder Matthew Herder suggests it may be time to re-examine the purpose of the U.S. Orphan Drug Act.