Author Archives: PLoS Medicine

PLOS Medicine at 10 Years: Two Imperatives

by The PLOS Medicine Editors

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The Causal Effect of Vitamin D Binding Protein (DBP) Levels on Calcemic and Cardiometabolic…

by Aaron Leong, Waheed Rehman, Zari Dastani, Celia Greenwood, Nicholas Timpson, Lisa Langsetmo, Claudie Berger, METASTROKE , Lei Fu, Betty Y. L. Wong, Suneil Malik, Rainer Malik, David A. Hanley, David E. C

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Sex-Specific Differences in Hemodialysis Prevalence and Practices and the Male-to-Female…

by Manfred Hecking, Brian A. Bieber, Jean Ethier, Alexandra Kautzky-Willer, Gere Sunder-Plassmann, Marcus D. Säemann, Sylvia P. B. Ramirez, Brenda W.

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Maternal Clinical Diagnoses and Hospital Variation in the Risk of Cesarean Delivery: Analyses…

by Katy B. Kozhimannil, Mariana C. Arcaya, S. V. Subramanian Background Cesarean delivery is the most common inpatient surgery in the United States, where 1.3 million cesarean sections occur annually, and rates vary widely by hospital.

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Variation in Caesarean Section Rates in the US: Outliers, Damned Outliers, and Statistics

by Gordon C. S. Smith

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How to Make More Published Research True

by John P. A. Ioannidis

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Developmental Profiles of Eczema, Wheeze, and Rhinitis: Two Population-Based Birth Cohort…

by Danielle C. M. Belgrave, Raquel Granell, Angela Simpson, John Guiver, Christopher Bishop, Iain Buchan, A. John Henderson, Adnan Custovic Background The term “atopic march” has been used to imply a natural progression of a cascade of symptoms from eczema to asthma and rhinitis through childhood. We hypothesize that this expression does not adequately describe the natural history of eczema, wheeze, and rhinitis during childhood

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Treatment of Infections in Young Infants in Low- and Middle-Income Countries: A Systematic…

by Anne CC Lee, Aruna Chandran, Hadley K. Herbert, Naoko Kozuki, Perry Markell, Rashed Shah, Harry Campbell, Igor Rudan, Abdullah H. Baqui Background Inadequate illness recognition and access to antibiotics contribute to high case fatality from infections in young infants (<2 months) in low- and middle-income countries (LMICs). We aimed to address three questions regarding access to treatment for young infant infections in LMICs: (1) Can frontline health workers accurately diagnose possible bacterial infection (pBI)?; (2) How available and affordable are antibiotics?; (3) How often are antibiotics procured without a prescription?</p> Methods and Findings We searched PubMed, Embase, WHO/Health Action International (HAI), databases, service provision assessments (SPAs), Demographic and Health Surveys, Multiple Indicator Cluster Surveys, and grey literature with no date restriction until May 2014. Data were identified from 37 published studies, 46 HAI national surveys, and eight SPAs

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Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies:…

by Karel G. M. Moons, Joris A. H. de Groot, Walter Bouwmeester, Yvonne Vergouwe, Susan Mallett, Douglas G

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Association of Medical Students’ Reports of Interactions with the Pharmaceutical and Medical…

by James S. Yeh, Kirsten E. Austad, Jessica M. Franklin, Susan Chimonas, Eric G. Campbell, Jerry Avorn, Aaron S.

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Description of 3,180 Courses of Chelation with Dimercaptosuccinic Acid in Children ≤5 y with…

by Natalie Thurtle, Jane Greig, Lauren Cooney, Yona Amitai, Cono Ariti, Mary Jean Brown, Michael J. Kosnett, Krystel Moussally, Nasir Sani-Gwarzo, Henry Akpan, Leslie Shanks, Paul I. Dargan Background In 2010, Médecins Sans Frontières (MSF) discovered extensive lead poisoning impacting several thousand children in rural northern Nigeria. An estimated 400 fatalities had occurred over 3 mo.

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Europe Needs a Central, Transparent, and Evidence-Based Approval Process for Behavioural…

by Fabrizio Faggiano, Elias Allara, Fabrizia Giannotta, Roberta Molinar, Harry Sumnall, Reinout Wiers, Susan Michie, Linda Collins, Patricia Conrod

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Hemoglobin A1c Levels and Risk of Severe Hypoglycemia in Children and Young Adults with Type 1…

by Beate Karges, Joachim Rosenbauer, Thomas Kapellen, Verena M. Wagner, Edith Schober, Wolfram Karges, Reinhard W. Holl Background Severe hypoglycemia is a major complication of insulin treatment in patients with type 1 diabetes, limiting full realization of glycemic control. It has been shown in the past that low levels of hemoglobin A1c (HbA1c), a marker of average plasma glucose, predict a high risk of severe hypoglycemia, but it is uncertain whether this association still exists. Based on advances in diabetes technology and pharmacotherapy, we hypothesized that the inverse association between severe hypoglycemia and HbA1c has decreased in recent years.

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Global Financing and Long-Term Technical Assistance for Multidrug-Resistant Tuberculosis:…

by Thomas J. Hwang, Salmaan Keshavjee

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