Author Archives: PLoSNTDs

Molecular genomic characterization of tick- and human-derived severe fever with…

by Seok-Min Yun, Su-Jin Park, Sun-Whan Park, WooYoung Choi, Hye Won Jeong, Young-Ki Choi, Won-Ja Lee Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne viral disease caused by the SFTS virus (SFTSV) from Bunyaviridae that is endemic in East Asia. However, the genetic and evolutionary characteristics shared between tick- and human-derived Korean SFTSV strains are still limited. Methodology/Principal findings In this study we identify, for the first time, the genome sequence of a tick (Haemaphysalis longicornis)-derived Korean SFTSV strain (designated as KAGWT) and compare this virus with recent human SFTSV isolates to identify the genetic variations and relationships among SFTSV strains.

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Recombinant vaccines of a CD4<sup>+</sup> T-cell epitope promote efficient control…

by Rodrigo Assunção Holanda, Julián Esteban Muñoz, Lucas Santos Dias, Leandro Buffoni Roque Silva, Julliana Ribeiro Alves Santos, Sthefany Pagliari, Érica Leandro Marciano Vieira, Tatiane Alves Paixão, Carlos Pelleschi Taborda, Daniel Assis Santos, Oscar Bruña-Romero Paracoccidioidomycosis (PCM) is an infectious disease endemic to South America, caused by the thermally dimorphic fungi Paracoccidioides. Currently, there is no effective human vaccine that can be used in prophylactic or therapeutic regimes.

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Household costs of hospitalized dengue illness in semi-rural Thailand

by Yesim Tozan, Pitcha Ratanawong, Maquines Odhiambo Sewe, Annelies Wilder-Smith, Pattamaporn Kittayapong Background Dengue-related illness is a leading cause of hospitalization and death in Thailand and other Southeast Asian countries, imposing a major economic burden on households, health systems, and governments. This study aims to assess the economic impact of hospitalized dengue cases on households in Chachoengsao province in eastern Thailand. Methods We conducted a prospective cost-of-illness study of hospitalized pediatric and adult dengue patients at three public hospitals.

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Platelet dysfunction contributes to bleeding complications in patients with probable…

by Rahajeng N. Tunjungputri, Muhammad Hussein Gasem, Willemijn van der Does, Pandu H. Sasongko, Bambang Isbandrio, Rolf T.

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<i>“Koko et les lunettes magiques”</i>: An educational entertainment tool to…

by Clémence Essé, Véronique A. Koffi, Abel Kouamé, Kouassi Dongo, Richard B. Yapi, Honorine M.

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Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the…

by Nada Abla, Jennifer Keiser, Mireille Vargas, Natalie Reimers, Helmut Haas, Thomas Spangenberg After more than 40 years of use, Praziquantel (PZQ) still remains the drug of choice for the treatment of intestinal and urogenital schistosomiasis. Its anti-parasitic activity resides primarily in the (R)-enantiomer. Hitherto neither the molecular target nor the pharmacokinetic-pharmacodynamic relationship have been fully elucidated.

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Estimating the prevalence and intensity of <i>Schistosoma mansoni</i> infection…

by Jared S. Bakuza, Matthew J. Denwood, Gamba Nkwengulila, Barbara K

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A scoring model for predicting prognosis of patients with severe fever with thrombocytopenia…

by Bei Jia, Xiaomin Yan, Yuxin Chen, Guiyang Wang, Yong Liu, Biyun Xu, Peixin Song, Yang Li, Yali Xiong, Weihua Wu, Yingying Hao, Juan Xia, Zhaoping Zhang, Rui Huang, Chao Wu Severe fever with thrombocytopenia syndrome (SFTS) is an emerging epidemic infectious disease caused by the SFTS bunyavirus (SFTSV) with an estimated high case-fatality rate of 12.7% to 32.6%. Currently, the disease has been reported in mainland China, Japan, Korea, and the United States.

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Differential virulence between Asian and African lineages of Zika virus

by Yannick Simonin, Debby van Riel, Philippe Van de Perre, Barry Rockx, Sara Salinas

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Low antibody prevalence against <i>Bacillus cereus</i> biovar…

by Fee Zimmermann, Susanne M. Köhler, Kathrin Nowak, Susann Dupke, Anne Barduhn, Ariane Düx, Alexander Lang, Hélène M. De Nys, Jan F

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Updated estimation of the impact of a Japanese encephalitis immunization program with live,…

by Shyam Raj Upreti, Nicole P. Lindsey, Rajendra Bohara, Ganga Ram Choudhary, Sushil Shakya, Mukunda Gautam, Jagat Narain Giri, Marc Fischer, Susan L. Hills Background Japanese encephalitis (JE) is a mosquito-borne disease that is associated with considerable morbidity and mortality in many Asian countries

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Mucosal leishmaniasis mimicking T-cell lymphoma in a patient receiving monoclonal antibody…

by Antonio Carlos Nicodemo, Daniel Fernandes Duailibi, Diego Feriani, Maria Irma Seixas Duarte, Valdir Sabbaga Amato

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Pyrethroid resistance alters the blood-feeding behavior in Puerto Rican <i>Aedes…

by Natasha M. Agramonte, Jeffrey R. Bloomquist, Ulrich R

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The clinical and microbiological characteristics of enteric fever in Cambodia, 2008-2015

by Laura M. F. Kuijpers, Thong Phe, Chhun H

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