Author Archives: PLoSNTDs

L-arginine supplementation reduces mortality and improves disease outcome in mice infected with…

by Sofía Carbajosa, Héctor O. Rodríguez-Angulo, Susana Gea, Carlos Chillón-Marinas, Cristina Poveda, María C. Maza, Diana Colombet, Manuel Fresno, Núria Gironès Chagas disease caused by Trypanosoma cruzi is a neglected disease that affects about 7 million people in Latin America, recently emerging on other continents due to migration.

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Modelling the large-scale yellow fever outbreak in Luanda, Angola, and the impact of…

by Shi Zhao, Lewi Stone, Daozhou Gao, Daihai He Background Yellow fever (YF), transmitted via bites of infected mosquitoes, is a life-threatening viral disease endemic to tropical and subtropical regions of Africa and South America. YF has largely been controlled by widespread national vaccination campaigns. Nevertheless, between December 2015 and August 2016, YF resurged in Angola, quickly spread and becoming the largest YF outbreak for the last 30 years.

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Occupational exposure to human <i>Mycobacterium bovis</i> infection: A systematic…

by Flora Vayr, Guillaume Martin-Blondel, Frederic Savall, Jean-Marc Soulat, Gaëtan Deffontaines, Fabrice Herin Background Mycobacterium bovis (M. bovis) is the main causative agent of bovine zoonotic tuberculosis. The aim of this systematic review is to highlight the occupational exposure to bovine tuberculosis due to M

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Multi-drug resistant non-typhoidal <i>Salmonella</i> associated with invasive…

by Adam Akullian, Joel M. Montgomery, Grace John-Stewart, Samuel I. Miller, Hillary S

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Harmonized clinical trial methodologies for localized cutaneous leishmaniasis and potential for…

by Piero Olliaro, Max Grogl, Marina Boni, Edgar M. Carvalho, Houda Chebli, Mamoudou Cisse, Ermias Diro, Gláucia Fernandes Cota, Astrid C. Erber, Endalamaw Gadisa, Farhad Handjani, Ali Khanesipour, Alejandro Llanos-Cuentas, Liliana López Carvajal, Lise Grout, Badre Eddine Lmimouni, Mourad Mokni, Mohammad Sami Nahzat, Afif Ben Salah, Yusuf Ozbel, Juan Miguel Pascale, Nidia Rizzo Molina, Joelle Rode, Gustavo Romero, José Antonio Ruiz-Postigo, Nancy Gore Saravia, Jaime Soto, Soner Uzun, Vahid Mashayekhi, Ivan Dario Vélez, Florian Vogt, Olga Zerpa, Byron Arana Introduction Progress with the treatment of cutaneous leishmaniasis (CL) has been hampered by inconsistent methodologies used to assess treatment effects.

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<i>Burkholderia pseudomallei</i> modulates host iron homeostasis to facilitate iron…

by Imke H. E. Schmidt, Claudia Gildhorn, Martha A

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Cognitive deficits and educational loss in children with schistosome infection—A systematic…

by Amara E. Ezeamama, Amaya L. Bustinduy, Allan K

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Isolation and complete genome analysis of neurotropic dengue virus serotype 3 from the…

by Rama Dhenni, Mulya Rahma Karyanti, Nina Dwi Putri, Benediktus Yohan, Frilasita A. Yudhaputri, Chairin Nisa Ma’roef, Araniy Fadhilah, Aditya Perkasa, Restuadi Restuadi, Hidayat Trimarsanto, Irawan Mangunatmadja, Jeremy P. Ledermann, Ronald Rosenberg, Ann M.

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Soil-transmitted helminth infection, loss of education and cognitive impairment in school-aged…

by Noel Pabalan, Eloisa Singian, Lani Tabangay, Hamdi Jarjanazi, Michael J. Boivin, Amara E. Ezeamama Background Evidence of an adverse influence of soil transmitted helminth (STH) infections on cognitive function and educational loss is equivocal.

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Mapping the geographical distribution of podoconiosis in Cameroon using parasitological,…

by Kebede Deribe, Amuam Andrew Beng, Jorge Cano, Abdel Jelil Njouendo, Jerome Fru-Cho, Abong Raphael Awah, Mathias Esum Eyong, Patrick W. Chounna Ndongmo, Emanuele Giorgi, David M.

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Experimental transmission of West Nile Virus and Rift Valley Fever Virus by <i>Culex…

by Renée Zakhia, Laurence Mousson, Marie Vazeille, Nabil Haddad, Anna-Bella Failloux West Nile virus (WNV) and Rift Valley fever virus (RVFV) are two emerging arboviruses transmitted by Culex pipiens species that includes two biotypes: pipiens and molestus. In Lebanon, human cases caused by WNV and RVFV have never been reported.

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Barriers of attendance to dog rabies static point vaccination clinics in Blantyre, Malawi

by Stella Mazeri, Andrew D Gibson, Natascha Meunier, Barend M.deC Bronsvoort, Ian G Handel, Richard J Mellanby, Luke Gamble Rabies is a devastating yet preventable disease that causes around 59,000 human deaths annually. Almost all human rabies cases are caused by bites from rabies-infected dogs. A large proportion of these cases occur in Sub Saharan Africa (SSA)

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Canine visceral leishmaniasis: Diagnosis and management of the reservoir living among us

by Bruno L. Travi, Anabela Cordeiro-da-Silva, Filipe Dantas-Torres, Guadalupe Miró This article reviews essential topics of canine visceral leishmaniasis (CVL) due to Leishmania infantum infection.

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The glutamine synthetase of <i>Trypanosoma cruzi</i> is required for its resistance…

by Marcell Crispim, Flávia Silva Damasceno, Agustín Hernández, María Julia Barisón, Ismael Pretto Sauter, Raphael Souza Pavani, Alexandre Santos Moura, Elizabeth Mieko Furusho Pral, Mauro Cortez, Maria Carolina Elias, Ariel Mariano Silber Trypanosoma cruzi, the etiological agent of Chagas disease, consumes glucose and amino acids depending on the environmental availability of each nutrient during its complex life cycle. For example, amino acids are the major energy and carbon sources in the intracellular stages of the T. cruzi parasite, but their consumption produces an accumulation of NH4+ in the environment, which is toxic.

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