by Lauren Gardner, Nan Chen, Sahotra Sarkar Background The 2015-16 Zika virus pandemic originating in Latin America led to predictions of a catastrophic global spread of the disease. Since the current outbreak began in Brazil in May 2015 local transmission of Zika has been reported in over 60 countries and territories, with over 750 thousand confirmed and suspected cases.
Author Archives: PLoSNTDs
by Brian L. Montgomery, Martin A. Shivas, Sonja Hall-Mendelin, Jim Edwards, Nicholas A.
by Glaucia Diniz Alessio, Fernanda Fortes de Araújo, Denise Fonseca Côrtes, Policarpo Ademar Sales Júnior, Daniela Cristina Lima, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Marcelo Antônio Pascoal Xavier, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Marta de Lana Distinct Trypanosoma cruzi genotypes have been considered relevant for patient management and therapeutic response Chagas disease. However, typing strategies for genotype-specific serodiagnosis of Chagas disease are still unavailable and requires standardization for practical application. In this study, an innovative TcI/TcVI/TcII Chagas Flow ATE-IgG2a technique was developed with applicability for universal and genotype-specific diagnosis of T
by Malgorzata Kesik-Brodacka, Agnieszka Lipiec, Monika Kozak Ljunggren, Luiza Jedlina, Katarzyna Miedzinska, Magdalena Mikolajczak, Andrzej Plucienniczak, Andrzej B. Legocki, Halina Wedrychowicz Background Cysteine proteinases of Fasciola hepatica are important candidates for vaccine antigens because of their role in fluke biology and host-parasite relationships.
by Maria Aparecida Shikanai Yasuda, Camila Gonçalves Sátolo, Noemia Barbosa Carvalho, Magda Maya Atala, Rosario Quiroga Ferrufino, Ruth Moreira Leite, Célia Regina Furucho, Expedito Luna, Rubens Antonio Silva, Marcia Hage, Caroline Medeji Ramos de Oliveira, Felipe Delatorre Busser, Vera Lucia Teixeira de Freitas, Dalva Marli Valerio Wanderley, Luzia Martinelli, Sonia Regina Almeida, Pedro Albajar Viñas, Nivaldo Carneiro Jr. Background/Methods In a pioneering cross-sectional study among Bolivian immigrants in the city of São Paulo, Brazil, the epidemiological profile, clinical manifestations and morbidity of Chagas disease were described. The feasibility of the management of Chagas disease at primary healthcare clinics using a biomedical and psychosocial interdisciplinary approach was also tested.
by Parnali Dhar-Chowdhury, Kishor Kumar Paul, C. Emdad Haque, Shakhawat Hossain, L.
by Nana-Kwadwo Biritwum, Dziedzom K. de Souza, Benjamin Marfo, Samuel Odoom, Bright Alomatu, Odame Asiedu, Abednego Yeboah, Tei E.
by Aiko Kurosawa, Kageaki Tojinbara, Hazumu Kadowaki, Katie Hampson, Akio Yamada, Kohei Makita Japan has been free from rabies since the 1950s. However, during the early 1900s several large-scale epidemics spread throughout the country.
by Robert E. Snyder, Claire E. Boone, Claudete A
by Elizabeth A. Cromwell, Steven T. Stoddard, Christopher M
by Peter J. Hotez, Serap Aksoy
by Julia A. Loos, Valeria A. Dávila, Christian Rodriguez Rodrigues, Romina Petrigh, Jorge A.
by Matt David Thomas Hitchings, Rebecca Freeman Grais, Marc Lipsitch Background The 2014–6 West African Ebola epidemic highlights the need for rigorous, rapid clinical trial methods for vaccines. A challenge for trial design is making sample size calculations based on incidence within the trial, total vaccine effect, and intracluster correlation, when these parameters are uncertain in the presence of indirect effects of vaccination.
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