Infectious Disease

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Republican health plan seen as a major setback for hepatitis C Medicaid patients

Amid a growing hepatitis C epidemic, federal austerity measures seen as a setback to infection control.  By Sony Salzman It’s been nearly 20 years since Read More

Meet the amazing cast behind a life-changing drug

It was well after midnight in San Francisco when Eugenio (“Geno”) de Hostos picked up the phone—but when his colleagues in China answered, he felt the familiar jolt of excitement. He’d felt the same thrill at dawn, talking to his colleagues in Switzerland. At five, in a call to Maryland with the US Food and […] ; ; ; ;Related StoriesWaking from sleeping sickness in the DRCThe surprising consequences of tuberculosisPATH is at SXSW ;

Photo: PATH/Lynn Heinisch.

Lessons from the front lines

In the midst of the 2014 Ebola outbreak in West Africa, a 21-year-old Guinean student came to a Dakar health clinic with symptoms of fever and diarrhea. The doctor considered Ebola, which had killed more than 1,000 people in neighboring Guinea. But the patient wasn’t bleeding. He denied having been in contact with Ebola patients […] ; ; ; ;Related StoriesIn Davos, Rx for epidemics: tech partnershipsInnovation is at the heart of SeattleOur 8 favorite photos of 2016 ;

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Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via…

by Justin Komguep Nono, Hlumani Ndlovu, Nada Abdel Aziz, Thabo Mpotje, Lerato Hlaka, Frank Brombacher Interleukin-4 receptor (IL-4Rα) is critical for the initiation of type-2 immune responses and implicated in the pathogenesis of experimental schistosomiasis. IL-4Rα mediated type-2 responses are critical for the control of pathology during acute schistosomiasis. However, type-2 responses tightly associate with fibrogranulomatous inflammation that drives host pathology during chronic schistosomiasis.


A prospective cohort study of the effectiveness of the primary hospital management of all…

by Seyed Shahmy, Senanayake A. M.


Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in…

by Justin Windingoudi Kaboré, Hamidou Ilboudo, Harry Noyes, Oumou Camara, Jacques Kaboré, Mamadou Camara, Mathurin Koffi, Veerle Lejon, Vincent Jamonneau, Annette MacLeod, Christiane Hertz-Fowler, Adrien Marie Gaston Belem, Enock Matovu, Bruno Bucheton, Issa Sidibe, for the TrypanoGEN Research Group as members of The H3Africa Consortium Background Human African trypanosomiasis (HAT), a lethal disease induced by Trypanosoma brucei gambiense, has a range of clinical outcomes in its human host in West Africa: an acute form progressing rapidly to second stage, spontaneous self-cure and individuals able to regulate parasitaemia at very low levels, have all been reported from endemic foci. In order to test if this clinical diversity is influenced by host genetic determinants, the association between candidate gene polymorphisms and HAT outcome was investigated in populations from HAT active foci in Guinea. Methodology and results Samples were collected from 425 individuals; comprising of 232 HAT cases, 79 subjects with long lasting positive and specific serology but negative parasitology and 114 endemic controls


Vector competence of populations of <i>Aedes aegypti</i> from three distinct cities…

by Sheila B. Agha, Edith Chepkorir, Francis Mulwa, Caroline Tigoi, Samwel Arum, Milehna M.


Expression of interferon-inducible chemokines and sleep/wake changes during early encephalitis…

by Claudia Laperchia, Chiara Tesoriero, Paul F. Seke-Etet, Valentina La Verde, Valeria Colavito, Gigliola Grassi-Zucconi, Jean Rodgers, Paul Montague, Peter G.


Correlation between mosquito larval density and their habitat physicochemical characteristics…

by Seyed Hassan Nikookar, Mahmoud Fazeli-Dinan, Shahyad Azari-Hamidian, Seyed Nouraddin Mousavinasab, Mohsen Aarabi, Seyyed Payman Ziapour, Yahya Esfandyari, Ahmadali Enayati Characteristics of mosquito larval habitats are important in determining whether they can survive and successfully complete their developmental stages. Therefore, data on the ecological factors affecting mosquito density and abundance especially the physicochemical properties of water of their breeding sites, can possibly be helpful in implementing larval management programs. Mosquito larvae were collected using a standard 350 ml dipper from fixed habitats including: artificial pool, river edge, creek and etc, in 30 villages of 16 counties from May-December 2014


The location of Australian Buruli ulcer lesions—Implications for unravelling disease…

by Arvind Yerramilli, Ee Laine Tay, Andrew J. Stewardson, Peter G. Kelley, Emma Bishop, Grant A.


A strategy for scaling up access to comprehensive care in adults with Chagas disease in endemic…

by Maria-Jesus Pinazo, Jimy Pinto, Lourdes Ortiz, Jareth Sánchez, Wilson García, Ruth Saravia, Mirko-R Cortez, Silvia Moriana, Enric Grau, Daniel Lozano, Joaquim Gascon, Faustino Torrico Background Bolivia has the highest prevalence of Chagas disease (CD) in the world (6.1%), with more than 607,186 people with Trypanosoma cruzi infection, most of them adults. In Bolivia CD has been declared a national priority. In 2009, the Chagas National Program (ChNP) had neither a protocol nor a clear directive for diagnosis and treatment of adults.


Persistent infection due to a small-colony variant of <i>Burkholderia…

by Jia-Xiang See, Samudi Chandramathi, Mahmood Ameen Abdulla, Jamuna Vadivelu, Esaki M. Shankar Background Melioidosis is a neglected tropical disease endemic across South East Asia and Northern Australia.


Increased hepatotoxicity among HIV-infected adults co-infected with <i>Schistosoma…

by Amon I. Marti, Soledad Colombe, Peter J. Masikini, Samuel E.


Assessment of risk of dengue and yellow fever virus transmission in three major Kenyan cities…

by Sheila B. Agha, David P. Tchouassi, Armanda D.


An enduring legacy of discovery: Margaret Stirewalt

by Lucie Henein, James J. Cody, Michael H.


Caprine brucellosis: A historically neglected disease with significant impact on public health

by Carlos A. Rossetti, Angela M.


The Forest through the Trees: Themes in Social Production of Health

Recently Professor Ayodele S Jegede of the Faculty of Social Sciences, delivered the 419th Inaugural Lecture at the University of Ibadan, Ibadan, Nigeria, during the 2016/2017 academic session.  Below Prof. Jegede shares an abstract of his lecture. Prof Ayodele S Jegede Knowledge of individual actor’s behaviour is a reflection of the society as tree to the forest. As forest produces large quantities of oxygen and takes in carbon dioxide, society produces the needed resources for human beings to survive through culture.


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