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Photo: PATH/Lynn Heinisch.

Lessons from the front lines

In the midst of the 2014 Ebola outbreak in West Africa, a 21-year-old Guinean student came to a Dakar health clinic with symptoms of fever and diarrhea. The doctor considered Ebola, which had killed more than 1,000 people in neighboring Guinea. But the patient wasn’t bleeding. He denied having been in contact with Ebola patients […] ; ; ; ;Related StoriesIn Davos, Rx for epidemics: tech partnershipsInnovation is at the heart of SeattleOur 8 favorite photos of 2016 ;

To Use or Not to Use: the Clinical Dilemma of Antimicrobials

    Understandably frustrated after 4 weeks of mild coughing, a nicely dressed businesswoman had come for an evaluation. I looked for infection in her Read More

Think scale! Engaging Private Pharmacies to Improve Public Health 

A version of this story first appeared on IDSA’s Science Speaks platform By Emily Delmotte Lisinopril 20 mg by mouth at 8am? Check. After verifying the Read More

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Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals…

by Thi Huyen Tram Nguyen, Jérémie Guedj, Xavier Anglaret, Cédric Laouénan, Vincent Madelain, Anne-Marie Taburet, Sylvain Baize, Daouda Sissoko, Boris Pastorino, Anne Rodallec, Géraldine Piorkowski, Sara Carazo, Mamoudou N. Conde, Jean-Luc Gala, Joseph Akoi Bore, Caroline Carbonnelle, Frédéric Jacquot, Hervé Raoul, Denis Malvy, Xavier de Lamballerie, France Mentré, JIKI study group Background In 2014–2015, we assessed favipiravir tolerance and efficacy in patients with Ebola virus (EBOV) disease (EVD) in Guinea (JIKI trial). Because the drug had never been used before for this indication and that high concentrations of the drugs were needed to achieve antiviral efficacy against EBOV, a pharmacokinetic model had been used to propose relevant dosing regimen


Unexpectedly high leprosy seroprevalence detected using a random surveillance strategy in…

by Marco Andrey C. Frade, Natália A.


Hydrocephalus and arthrogryposis in an immunocompetent mouse model of ZIKA teratogeny: A…

by Jose Xavier-Neto, Murilo Carvalho, Bruno dos Santos Pascoalino, Alisson Campos Cardoso, Ângela Maria Sousa Costa, Ana Helena Macedo Pereira, Luana Nunes Santos, Ângela Saito, Rafael Elias Marques, Juliana Helena Costa Smetana, Silvio Roberto Consonni, Carla Bandeira, Vivian Vasconcelos Costa, Marcio Chaim Bajgelman, Paulo Sérgio Lopes de Oliveira, Marli Tenorio Cordeiro, Laura Helena Vega Gonzales Gil, Bianca Alves Pauletti, Daniela Campos Granato, Adriana Franco Paes Leme, Lucio Freitas-Junior, Carolina Borsoi Moraes Holanda de Freitas, Mauro Martins Teixeira, Estela Bevilacqua, Kleber Franchini The teratogenic mechanisms triggered by ZIKV are still obscure due to the lack of a suitable animal model. Here we present a mouse model of developmental disruption induced by ZIKV hematogenic infection. The model utilizes immunocompetent animals from wild-type FVB/NJ and C57BL/6J strains, providing a better analogy to the human condition than approaches involving immunodeficient, genetically modified animals, or direct ZIKV injection into the brain


In Letter, Members Of Congress Urge U.S. Army Not To Exclusively License Experimental Zika…

STAT: Lawmakers urge U.S. Army not to issue exclusive license to Sanofi for a Zika vaccine “Nearly a dozen members of Congress are urging the U.S. Army not to issue an exclusive license to Sanofi Pasteur to develop a vaccine for the Zika virus over concerns the product may be priced too high for many…More


The Lancet Infectious Diseases Interviews Finalists For WHO Director General Position

The Lancet Infectious Diseases: WHO Director General shortlist chosen “On 25 January 2017, the WHO Executive Board announced the shortlisted candidates for the post of director general. Talha Burki speaks with the contenders…” (Burki, March 2017).


African Business Magazine Examines How Product Development Partnerships Help Drive R&D, Markets…

African Business Magazine: Partnerships to fight disease “…Investing in the discovery, development, and manufacture of drugs to combat tropical and poverty-related diseases in African countries with limited resources to fund research or pay for treatments was a commercial non-starter. … The product development partnership (PDP) model, which emerged in the late 90s, was a response…More


Africa CDC In ‘Unique Position’ To Promote African Public Health But Uncertainty Over…

The Lancet Infectious Diseases: A new day for African public health Editorial Board “…The [Africa Centers for Disease Control and Prevention (Africa CDC)] is Africa’s first continent-wide public health agency … The aim of the Africa CDC will be to establish early warning and response surveillance systems, respond to emergencies, build capacity, and provide technical…More


HIV and Hormonal Contraception: Bench and Bedside

No abstract available


The historical ecology of malaria in Ethiopia: Deposing the spirits

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Prescription of Postexposure Prophylaxis for HIV-1 in the Emergency Room: Correct Transmission…

Background: Limited data are available about the accuracy of postexposure prophylaxis (PEP) prescription in the emergency rooms.


HIV-Related Sexual Risk Among Transgender Men Who Are Gay, Bisexual, or Have Sex With Men

Background: This study is among the first to examine factors associated with HIV-related sexual risk among transgender men and other transmasculine persons who are gay, bisexual, or have sex with men (T-GBMSM).


Lessons from the front lines

Photo: PATH/Lynn Heinisch.

In the midst of the 2014 Ebola outbreak in West Africa, a 21-year-old Guinean student came to a Dakar health clinic with symptoms of fever and diarrhea. The doctor considered Ebola, which had killed more than 1,000 people in neighboring Guinea. But the patient wasn’t bleeding. He denied having been in contact with Ebola patients […] ; ; ; ;Related StoriesIn Davos, Rx for epidemics: tech partnershipsInnovation is at the heart of SeattleOur 8 favorite photos of 2016 ;


CROI 2017: Coming “youth bulge” presents HIV responses with impetus, obstacles,…

Categories: CROI 2017SEATTLE – They are curious, impulsive and renownedly reckless. Studies have indicated they remain blissfully unaware of their risks, and unequipped to face them. Now, their numbers are growing fastest  in countries that are home to great risks — where rates of HIV infection are among the world’s highest and where current approaches to testing and treatment already […](Read more…)


Cynomolgus macaques naturally infected with <i>Trypanosoma cruzi</i>-I exhibit an…

by Danielle Marquete Vitelli-Avelar, Renato Sathler-Avelar, Armanda Moreira Mattoso-Barbosa, Nicolas Gouin, Marcelo Perdigão-de-Oliveira, Leydiane Valério-dos-Reis, Ronaldo Peres Costa, Silvana Maria Elói-Santos, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Edward J. Dick Jr., Gene B. Hubbard, Jane F


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