Infectious Disease

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Meet the amazing cast behind a life-changing drug

It was well after midnight in San Francisco when Eugenio (“Geno”) de Hostos picked up the phone—but when his colleagues in China answered, he felt the familiar jolt of excitement. He’d felt the same thrill at dawn, talking to his colleagues in Switzerland. At five, in a call to Maryland with the US Food and […] ; ; ; ;Related StoriesWaking from sleeping sickness in the DRCThe surprising consequences of tuberculosisPATH is at SXSW ;

Photo: PATH/Lynn Heinisch.

Lessons from the front lines

In the midst of the 2014 Ebola outbreak in West Africa, a 21-year-old Guinean student came to a Dakar health clinic with symptoms of fever and diarrhea. The doctor considered Ebola, which had killed more than 1,000 people in neighboring Guinea. But the patient wasn’t bleeding. He denied having been in contact with Ebola patients […] ; ; ; ;Related StoriesIn Davos, Rx for epidemics: tech partnershipsInnovation is at the heart of SeattleOur 8 favorite photos of 2016 ;

To Use or Not to Use: the Clinical Dilemma of Antimicrobials

    Understandably frustrated after 4 weeks of mild coughing, a nicely dressed businesswoman had come for an evaluation. I looked for infection in her Read More

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Burundi: when will citizens see real protection from malaria?

Preliminary findings from Burundi’s 2015-16 DHS have been made available. The country has a long way to go to meet targets for basic control of malaria. LLIN availability by household is an overall disappointing 32%. Ironically there is greater coverage of households in in urban areas (50%) than rural (30%). There is also great variation among the provinces with 52% coverage in Bujumbura metropolitan but only 19% in Canzuko.


Thank You for Supporting END7! Changes are coming…

by Kathryn McGrath It’s been five years since the Sabin Vaccine Institute launched the END7 campaign to end neglected tropical diseases (NTDs). With your support, we mobilized funding to support programs that treated more than 50 million people, helped increase US and UK funding for NTDs and spread awareness of the global NTD burden. As […]


Chronic <i>Trichuris muris</i> infection causes neoplastic change in the intestine…

by Kelly S. Hayes, Laura J. Cliffe, Alison J.


Urban Chikungunya in the Middle East and North Africa: A systematic review

by John M. Humphrey, Natalie B. Cleton, Chantal B


Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP…

by Melissa C. Sanchez, Katina V.


Novel inference models for estimation of abundance, survivorship and recruitment in mosquito…

by Daniel Antunes Maciel Villela, Gabriela de Azambuja Garcia, Rafael Maciel-de-Freitas Background Experiments involving mosquito mark-release-recapture (MRR) design are helpful to determine abundance, survival and even recruitment of mosquito populations in the field. Obstacles in mosquito MRR protocols include marking limitations due to small individual size, short lifespan, low efficiency in capturing devices such as traps, and individual removal upon capture. These limitations usually make MRR analysis restricted to only abundance estimation or a combination of abundance and survivorship, and often generate a great degree of uncertainty about the estimations


A study of ticks and tick-borne livestock pathogens in Pakistan

by Shahid Karim, Khemraj Budachetri, Nabanita Mukherjee, Jaclyn Williams, Asma Kausar, Muhammad Jawadul Hassan, Steven Adamson, Scot E. Dowd, Dmitry Apanskevich, Abdullah Arijo, Zia Uddin Sindhu, Muhammad Azam Kakar, Raja Muhammad Dilpazir Khan, Shafiq Ullah, Muhammad Sohail Sajid, Abid Ali, Zafar Iqbal Background As obligate blood-feeding arthropods, ticks transmit pathogens to humans and domestic animals more often than other arthropod vectors. Livestock farming plays a vital role in the rural economy of Pakistan, and tick infestation causes serious problems with it


Interleukin-4 receptor alpha is still required after Th2 polarization for the maintenance and…

by Justin Komguep Nono, Hlumani Ndlovu, Nada Abdel Aziz, Thabo Mpotje, Lerato Hlaka, Frank Brombacher There is currently no vaccine against parasitic nematodes and the knowledge on the mechanisms by which protective immunity against this class of parasites is achieved is continuously expanding. Nematode parasites trigger a host protective type 2 immune response via interleukin-4 receptor alpha (IL-4Rα). Despite this central role, it is not known whether IL-4Rα has a role in maintaining host type 2 immune responses following polarization.


Devex Profiles Former Global Fund Executive Director Mark Dybul, Discusses Continuing Efforts…

Devex: The gospel according to Mark Dybul, the man working to end three plagues “…After four years as the Global Fund’s executive director — during which time he helmed two multi-billion dollar fundraising efforts and helped restore the embattled Swiss organization’s reputation as a global health leader — Dybul stepped down last month at the…More


HHS Secretary Price Says Allowing Ebola-Infected Health Workers Back Into Country ‘A Moral…

The Atlantic: HHS Secretary Defies Trump on Ebola Travel Ban “At the height of the Ebola outbreak in 2014, days before the World Health Organization declared it an international public health emergency, Donald Trump tweeted: ‘The U.S. cannot allow EBOLA infected people back. People that go to far away places to help out are great-but…More


U.N. Human Rights Council Adopts Resolution On Right To Health; U.S. Voices Opposition To…

Intellectual Property Watch: U.N. Human Rights Council Adopts Access To Medicines Resolution “The United Nations Human Rights Council [Friday] adopted a resolution on the right to health in relation to the U.N. 2030 Sustainable Development Goals (SDGs), including a call for medicines and vaccines access for all. The resolution also requested the U.N. human rights…More


NIAID Director Anthony Fauci Speaks With Devex About Working With Different U.S. Presidential…

The Atlantic: The Truth Teller “…[Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases,] seemed surprised at the suggestion that he might do something other than what he’s been doing since he began leading the institute in 1984 — trying to protect people from diseases like Ebola, Zika, and HIV. This is…More


Suppression of chikungunya virus replication and differential innate responses of human…

by Mariana Ruiz Silva, José A. Aguilar Briseño, Vinit Upasani, Heidi van der Ende-Metselaar, Jolanda M.


Evaluation of different serological assays for early diagnosis of leptospirosis in Martinique…

by Christophe Courdurie, Yohann Le Govic, Pascale Bourhy, Dorothee Alexer, Karine Pailla, Rafaelle Theodose, Raymond Cesaire, Jacques Rosine, Patrick Hochedez, Claude Olive Background Leptospirosis is a potentially life-threatening but curable zoonosis whose prognosis depends on accurate and timely diagnosis. Because of its non-specific clinical presentation, laboratory testing is essential to confirm the diagnosis.


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