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201209_meningitis

Appearance Of New Meningitis Strain In Niger Prompts Warning Of Possibly Worse Outbreak In 2016

Lancet Infectious Diseases: Meningitis outbreak in Niger is an urgent warning “In most regards, the meningitis epidemic that struck Niger earlier this year was not unusual. But … [t]he outbreak in Niger was caused by a new strain of meningitis C. Serogroup C had been thought only to be a serious problem in Western Europe…More

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First MERS vaccine heads for human trials

Firms plan to take on research after tests show vaccine protects monkeys from Middle East respiratory syndrome.

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Is a Cholera Outbreak Preventable in Post-earthquake Nepal?

by Eric J. Nelson, Jason R. Andrews, Stacey Maples, Michele Barry, John D.

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Improved Quantification, Propagation, Purification and Storage of the Obligate Intracellular…

by Suparat Giengkam, Alex Blakes, Peemdej Utsahajit, Suwittra Chaemchuen, Sharanjeet Atwal, Stuart D. Blacksell, Daniel H. Paris, Nicholas P.


rPbPga1 from Paracoccidioides brasiliensis Activates Mast Cells and Macrophages via NFkB

by Clarissa Xavier Resende Valim, Elaine Zayas Marcelino da Silva, Mariana Aprigio Assis, Fabricio Freitas Fernandes, Paulo Sergio Rodrigues Coelho, Constance Oliver, Maria Célia Jamur Background The fungus Paracoccidioides brasiliensis is the leading etiological agent of paracoccidioidomycosis (PCM), a systemic granulomatous disease that typically affects the lungs. Cell wall components of P. brasiliensis interact with host cells and influence the pathogenesis of PCM


Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with…

by Daniel H. Paris, Femke Stephan, Ingrid Bulder, Diana Wouters, Tom van der Poll, Paul N. Newton, Nicholas P.


Bile Salts Modulate the Mucin-Activated Type VI Secretion System of Pandemic Vibrio cholerae

by Verena Bachmann, Benjamin Kostiuk, Daniel Unterweger, Laura Diaz-Satizabal, Stephen Ogg, Stefan Pukatzki The causative agent of cholera, Vibrio cholerae, regulates its diverse virulence factors to thrive in the human small intestine and environmental reservoirs. Among this pathogen’s arsenal of virulence factors is the tightly regulated type VI secretion system (T6SS). This system acts as an inverted bacteriophage to inject toxins into competing bacteria and eukaryotic phagocytes


The Diversity and Geographical Structure of Orientia tsutsugamushi Strains from Scrub Typhus…

by Rattanaphone Phetsouvanh, Piengchan Sonthayanon, Sasithon Pukrittayakamee, Daniel H. Paris, Paul N. Newton, Edward J


Ebola, The Executive Summary: August 28, 2015

To give you deeper insight into what’s happening in the Ebola outbreak, we’ve organized the latest developments in a curated weekly summary.


WHO Promotes WASH As Strategy To Prevent NTDs

News outlets report on the WHO’s new global strategy to prevent neglected tropical diseases through improved access to water, sanitation, and hygiene. Reuters: WHO promotes water, sanitation to battle neglected tropical diseases “Water, sanitation, and hygiene are part of a new World Health Organization strategy to fight neglected tropical diseases which afflict more than 1.5…More


The Economist Publishes Infographics On West African Ebola Outbreak

The Economist: Ebola in graphics: The toll of a tragedy The news magazine uses data from multiple sources, including the WHO and other U.N. agencies, as well as patient databases, to provide infographics on the Ebola outbreak in West Africa (8/27).


Child survival and drug resistance

I consider it my life’s mission to catalyze innovations and mentor startups that would help develop a cutting edge biotechnology industry for India and the world. This would simultaneously help solve some of India’s pressing public health impact problems. read more


Cooperation, Partnership Essential To Preparing For, Responding To Disease Outbreaks Like Ebola

The Lancet: An Ebola vaccine: first results and promising opportunities Editorial Board “[On August 3,] The Lancet publishe[d] the first results from a phase 3 cluster randomized trial of a novel Ebola virus vaccine. The study, sponsored and led by WHO, is a remarkable scientific and logistical achievement. … [I]f the evidence proves sufficient for…More


A simple, high-throughput, colourimetric, field applicable loop-mediated isothermal…

Background: To detect all malaria infections in elimination settings sensitive, high throughput and field deployable diagnostic tools are required.


Specific expression and export of the Plasmodium falciparum Gametocyte EXported Protein-5 marks…

Background: Plasmodium falciparum sexual development plays a fundamental role in the transmission and spread of malaria.


Genetic determinants of anti-malarial acquired immunity in a large multi-centre study

Background: Many studies report associations between human genetic factors and immunity to malaria but few have been reliably replicated.


Do holes in long-lasting insecticidal nets compromise their efficacy against pyrethroid…

Background: Resistance of malaria vectors to pyrethroids threatens the effectiveness of long-lasting insecticidal nets (LLINs) as a tool for malaria control.


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