Malaria

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“Access to information literally saves lives”: free access to UpToDate in LMICs

This week, Yannis Valtis joined us for a short conversation about a new paper he and colleagues recently published in BMJ Global Health. Their study Read More

Malaria burden and costs of intensified control in Bhutan, 2006–14: an…

The malaria burden in Bhutan decreased significantly during the study period with high coverage of long-lasting insecticidal nets. The foreseeable challenges that require national attention to maintain a malaria-free status after elimination are importation of malaria, especially from India; continued protection of the population in endemic districts through complete coverage with long-lasting insecticidal nets and indoor residual spraying; and exploration of local funding modalities post-elimination in the event of a reduction in international funding.

Lifting the Patent Barrier to New Drugs and Energy Sources – The New York Times

Strict patents on technology have had the effect of hindering global progress in some fields, especially in combating disease and climate change. Source: Lifting the Read More

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The Forest through the Trees: Themes in Social Production of Health

Recently Professor Ayodele S Jegede of the Faculty of Social Sciences, delivered the 419th Inaugural Lecture at the University of Ibadan, Ibadan, Nigeria, during the 2016/2017 academic session.  Below Prof. Jegede shares an abstract of his lecture. Prof Ayodele S Jegede Knowledge of individual actor’s behaviour is a reflection of the society as tree to the forest. As forest produces large quantities of oxygen and takes in carbon dioxide, society produces the needed resources for human beings to survive through culture.


A new method for sequencing the hypervariable Plasmodium falciparum gene var2csa from clinical…

VAR2CSA, a member of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family, mediates the binding of P.


Evaluation of piperonyl butoxide in enhancing the efficacy of pyrethroid insecticides against…

Malaria vector control methods involving the use of pyrethroids remain the strategies being used against malaria vectors in Ghana.


Do the venous blood samples replicate malaria parasite densities found in capillary blood? A…

The measure of new drug- or vaccine-based approaches for malaria control is based on direct membrane feeding assays (DMFAs) where gametocyte-infected blood samples are offered to mosquitoes through an artifici…


Modelling the benefits of long-acting or transmission-blocking drugs for reducing Plasmodium…

Anti-malarial drugs are an important tool for malaria control and elimination.


Which intervention is better for malaria vector control: insecticide mixture long-lasting…

Malaria control today is threatened by widespread insecticide resistance in vector populations.


The development of an ivermectin-based attractive toxic sugar bait (ATSB) to target Anopheles…

An increasing number of countries in sub-Saharan Africa are moving towards malaria-elimination, mostly thanks to successful vector control campaigns.


Circulating microRNAs in malaria infection: bench to bedside

Severe malaria has a poor prognosis with a morbidity rate of 80% in tropical areas.


Asymptomatic and Sub-Microscopic Malaria: a Challenge to Elimination Efforts

WHO says that, “In settings where malaria is actively being eliminated or has been eliminated, a “case” is the occurrence of any confirmed malaria infection with or without symptoms.” Several recent studies describe the importance of paying attention to asymptomatic infections. In the Bagamoyo District of Tanzania Sumari and colleagues collected blood samples and examined them for Plasmodium falciparum prevalence using rapid diagnostic test (RDT), light microscopy (LM) and reverse transcription quantitative PCR. While overall prevalence was higher in symptomatic children using all three methods, asymptomatic children had a higher prevalence of gametocytes using light microscopy and PCR.  They concluded that, “The higher gametocytemia observed in asymptomatic children indicates the reservoir infections and points to the need for detection and treatment of both asymptomatic and symptomatic malaria.” The health effects of asymptomatic plasmodial infections (API) on children were documented in Rwanda. These included “Plasmodium infection was associated with anaemia, fever, underweight, clinically assessed malnutrition and histories of fever, tiredness, weakness, poor appetite, abdominal pain, and vomiting” and were generally more common with submicroscopic infection


Clinical and molecular surveillance of artemisinin resistant falciparum malaria in Myanmar…

Emergence of artemisinin-resistant malaria in Southeast Asian countries threatens the global control of malaria.


Artemisinin combination therapy mass drug administration in a setting of low malaria…

Mass drug administration (MDA) appears to be effective in reducing the risk of malaria parasitaemia.


Life-span of in vitro differentiated Plasmodium falciparum gametocytes

The sexual stages (gametocytes) of Plasmodium falciparum do not directly contribute to the pathology of malaria but are essential for transmission of the parasite from the human host to the mosquito.


The Duffy binding protein (PkDBPαII) of Plasmodium knowlesi from Peninsular Malaysia and…

The zoonotic Plasmodium knowlesi is a major cause of human malaria in Malaysia.


Barriers to routine G6PD testing prior to treatment with primaquine

Primaquine is essential for the radical cure of vivax malaria, however its broad application is hindered by the risk of drug-induced haemolysis in individuals with glucose-6-phosphate-dehydrogenase (G6PD) defi…


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