by Karin L. Schiøler, Michael Alifrangis, Uriel Kitron, Flemming Konradsen
Neglected Tropical Diseases
Angola is grappling with a yellow fever outbreak, which has infected more than 450 people and killed 178 – the first epidemic of the disease to hit the country in 30 years. The outbreak, which was first reported in the capital city Luanda in December 2015, has since spread to 6 of the country’s 18
Unexplained meat bans can alienate people and hurt livelihoods. Salome Bukachi proposes ways to improve response.
by Reeta Subramaniam (Mani)
by Debbie-Ann Shirley, Shannon Moonah Background Amebic colitis, caused by intestinal infection with the parasite, Entamoeba histolytica, is a common cause of diarrhea worldwide. Fulminant amebic colitis is the most devastating complication of this infection, associated with both high mortality and morbidity. We conducted a review of the English literature to describe cases of fulminant amebic colitis associated with exposure to corticosteroid medications in order to identify the risk factors for poor outcome and determine difficulties in diagnosis and treatment.
by Peter J. Hotez
by Luther A. Bartelt, David T.
by Susan Meiring, Melony Fortuin-de Smidt, Ranmini Kularatne, Halima Dawood, Nelesh P. Govender, GERMS-SA Background We aimed to establish the prevalence of amphotericin B deoxycholate (AmBd)-related toxicities among South African patients with cryptococcosis and determine adherence to international recommendations to prevent, monitor and manage AmBd-related toxicities. Methods Clinical data were collected from cases of laboratory-confirmed cryptococcosis at 25 hospitals, October 2012 –February 2013
by Kathryn Shaw-Saliba, Richard Thomson-Luque, Nicanor Obaldía III, Marlon Nuñez, Sahir Dutary, Caeul Lim, Samantha Barnes, Clemens H. M. Kocken, Manoj T.
by Florencia Ferraro, Alicia Merlino, Nicolás dell´Oca, Jorge Gil, José F. Tort, Mercedes Gonzalez, Hugo Cerecetto, Mauricio Cabrera, Ileana Corvo Background Increased reports of human infections have led fasciolosis, a widespread disease of cattle and sheep caused by the liver flukes Fasciola hepatica and Fasciola gigantica, to be considered an emerging zoonotic disease. Chemotherapy is the main control measure available, and triclabendazole is the preferred drug since is effective against both juvenile and mature parasites
by Seung-Ji Kang, Hye-Mi Jin, Eun Jeong Won, Young-Nan Cho, Hyun-Ju Jung, Yong-Soo Kwon, Hae Jin Kee, Jae Kyun Ju, Jung-Chul Kim, Uh Jin Kim, Hee-Chang Jang, Sook-In Jung, Seung-Jung Kee, Yong-Wook Park Background Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections. However, little is known about the role of MAIT cells in Orientia tsutsugamushi infection.
by Anke Harenberg, Aymeric de Montfort, Frédérique Jantet-Blaudez, Matthew Bonaparte, Florence Boudet, Melanie Saville, Nicholas Jackson, Bruno Guy Background Two large-scale efficacy studies with the recombinant yellow fever-17D–dengue virus, live-attenuated, tetravalent dengue vaccine (CYD-TDV) candidate undertaken in Asia (NCT01373281) and Latin America (NCT01374516) demonstrated significant protection against dengue disease during two years’ active surveillance (active phase). Long-term follow up of participants for breakthrough disease leading to hospitalization is currently ongoing (hospital phase). Methodology/Principal findings We assessed the cytokine profile in acute sera from selected participants hospitalized (including during the active phase) up to the beginning of the second year of long-term follow up for both studies.
by Jill N. Ulrich, John C.
by Carla Cangalaya, Javier A. Bustos, Juan Calcina, Ana Vargas-Calla, Diego Suarez, Armando E.
by Dennis Hanke, Conrad M. Freuling, Susanne Fischer, Karsten Hueffer, Kris Hundertmark, Susan Nadin-Davis, Denise Marston, Anthony R.
by Osama M. E. Seidahmed, Elfatih A.
by Irina V. Saltykova, Vjacheslav A.