by Eric J. Nelson, Jason R. Andrews, Stacey Maples, Michele Barry, John D.
Neglected Tropical Diseases
A new study on a Dengue Vaccine from The New England Journal of Medicine demonstrates an unexplained higher incidence of hospitalization for dengue in year 3 Read More
Just US$300 million a year would greatly improve drug delivery for neglected tropical diseases, says coalition.
by Rattanaphone Phetsouvanh, Piengchan Sonthayanon, Sasithon Pukrittayakamee, Daniel H. Paris, Paul N. Newton, Edward J
by Suparat Giengkam, Alex Blakes, Peemdej Utsahajit, Suwittra Chaemchuen, Sharanjeet Atwal, Stuart D. Blacksell, Daniel H. Paris, Nicholas P.
by Clarissa Xavier Resende Valim, Elaine Zayas Marcelino da Silva, Mariana Aprigio Assis, Fabricio Freitas Fernandes, Paulo Sergio Rodrigues Coelho, Constance Oliver, Maria Célia Jamur Background The fungus Paracoccidioides brasiliensis is the leading etiological agent of paracoccidioidomycosis (PCM), a systemic granulomatous disease that typically affects the lungs. Cell wall components of P. brasiliensis interact with host cells and influence the pathogenesis of PCM
by Daniel H. Paris, Femke Stephan, Ingrid Bulder, Diana Wouters, Tom van der Poll, Paul N. Newton, Nicholas P.
by Verena Bachmann, Benjamin Kostiuk, Daniel Unterweger, Laura Diaz-Satizabal, Stephen Ogg, Stefan Pukatzki The causative agent of cholera, Vibrio cholerae, regulates its diverse virulence factors to thrive in the human small intestine and environmental reservoirs. Among this pathogen’s arsenal of virulence factors is the tightly regulated type VI secretion system (T6SS). This system acts as an inverted bacteriophage to inject toxins into competing bacteria and eukaryotic phagocytes
News outlets report on the WHO’s new global strategy to prevent neglected tropical diseases through improved access to water, sanitation, and hygiene. Reuters: WHO promotes water, sanitation to battle neglected tropical diseases “Water, sanitation, and hygiene are part of a new World Health Organization strategy to fight neglected tropical diseases which afflict more than 1.5…More
by Xin Zhao, Thiago Luiz Alves e Silva, Laura Cronin, Amy F. Savage, Michelle O’Neill, Barbara Nerima, Loyce M. Okedi, Serap Aksoy Tsetse are vectors of pathogenic trypanosomes, agents of human and animal trypanosomiasis in Africa.
by Sima Rafati, Shaden Kamhawi, Jesus G. Valenzuela, Mostafa Ghanei
by Md. Hafiz Uddin, Min-Ho Choi, Woo Ho Kim, Ja-June Jang, Sung-Tae Hong Background Clonorchis sinensis is a group-I bio-carcinogen for cholangiocarcinoma (CCA). Although the epidemiological evidence links clonorchiasis and CCA, the underlying molecular mechanism involved in this process is poorly understood.
by Hong-Ru Zhu, Lu Liu, Xiao-Nong Zhou, Guo-Jing Yang Background Schistosomiasis japonica is a parasitic disease that remains endemic in seven provinces in the People’s Republic of China (P.R. China). One of the most important measures in the process of schistosomiasis elimination in P.R
by Néstor A. Guerrero, Mercedes Camacho, Luis Vila, Miguel A. Íñiguez, Carlos Chillón-Marinas, Henar Cuervo, Cristina Poveda, Manuel Fresno, Núria Gironès Inflammation plays an important role in the pathophysiology of Chagas disease, caused by Trypanosoma cruzi.
by Anderson Messias Rodrigues, Geisa Ferreira Fernandes, Leticia Mendes Araujo, Paula Portella Della Terra, Priscila Oliveira dos Santos, Sandro Antonio Pereira, Tânia Maria Pacheco Schubach, Eva Burger, Leila Maria Lopes-Bezerra, Zoilo Pires de Camargo Background Sporothrix schenckii and associated species are agents of human and animal sporotrichosis that cause large sapronoses and zoonoses worldwide. Epidemiological surveillance has highlighted an overwhelming occurrence of the highly pathogenic fungus Sporothrix brasiliensis during feline outbreaks, leading to massive transmissions to humans.
by Nicholas J. Gow, Robert N.
by David Roquis, Julie M. J. Lepesant, Marion A.