by Pamela A. Kolopack, Janet A.
Neglected Tropical Diseases
by Sarah J. Wynwood, Mary-Anne A. Burns, Glenn C
This week, The New England Journal of Medicine features an excellent review article and interactive graphic on the recent emergence and spread of Chikungunya Virus. Read More
by Janna M. Schurer, Ellen Rafferty, Marwa Farag, Wu Zeng, Emily J.
by Danilo O. Carvalho, Andrew R. McKemey, Luiza Garziera, Renaud Lacroix, Christl A.
by Geoffrey K. Isbister, Kalana Maduwage, Ana Saiao, Nicholas A. Buckley, Shaluka F
by Kathleen E. Mach, Ruchika Mohan, Shailja Patel, Pak Kin Wong, Michael Hsieh, Joseph C. Liao
by Chung-Tao Tang, Pi-Chun Li, I-Ju Liu, Mei-Ying Liao, Chiung-Yi Chiu, Day-Yu Chao, Han-Chung Wu Dengue virus (DENV), a global disease, is divided into four serotypes (DENV1-4). Cross-reactive and non-neutralizing antibodies against envelope (E) protein of DENV bind to the Fcγ receptors (FcγR) of cells, and thereby exacerbate viral infection by heterologous serotypes via antibody-dependent enhancement (ADE). Identification and modification of enhancing epitopes may mitigate enhancement of DENV infection
by Chao-Fu Yang, Cheng-Hsun Tu, Yin-Ping Lo, Chih-Chieh Cheng, Wei-June Chen Dengue virus (DENV) is naturally transmitted by mosquitoes to humans, infecting cells of both hosts. Unlike in mammalian cells, DENV usually does not cause extremely deleterious effects on cells of mosquitoes. Despite this, clustered progeny virions were found to form infection foci in a high density cell culture.
by Victor S. Santos, Laudice S. Oliveira, Fabrícia D
by Chun-hua Gao, Yue-tao Yang, Feng Shi, Jun-yun Wang, Dietmar Steverding, Xia Wang Background Visceral leishmaniasis (VL) is a life-threatening disease caused by protozoan parasites of the Leishmania donovani complex. Early case detection followed by adequate treatment is essential to the control of VL. However, the available diagnostic tests are either invasive and require considerable expertise (parasitological demonstration of the parasite in tissue smears) or unable to distinguish between past and active infection (serological methods)
by Cristian Koepfli, Priscila T. Rodrigues, Tiago Antao, Pamela Orjuela-Sánchez, Peter Van den Eede, Dionicia Gamboa, Nguyen van Hong, Jorge Bendezu, Annette Erhart, Céline Barnadas, Arsène Ratsimbasoa, Didier Menard, Carlo Severini, Michela Menegon, Bakri Y.
by Michael Marks, Samantha Katz, Kai-Hua Chi, Ventis Vahi, Yongcheng Sun, David C. Mabey, Anthony W. Solomon, Cheng Y
by Jennifer L. Ginther, Mark Mayo, Stephanie D. Warrington, Mirjam Kaestli, Travis Mullins, David M
Global Network for Neglected Tropical Diseases’ “End the Neglect”: 3rd Progress Report on The London Declaration on Neglected Tropical Diseases Released Kathryn McGrath, communications manager at the Sabin Vaccine Institute, notes, “Uniting to Combat Neglected Tropical Diseases released its third progress report on the London Declaration on Neglected Tropical Diseases on June 25, 2015.” She…More
by Yixin H. Ye, Alison M. Carrasco, Francesca D.
by Tiffany M. Mott, Sudhamathi Vijayakumar, Elena Sbrana, Janice J. Endsley, Alfredo G