Neglected Tropical Diseases

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It was well after midnight in San Francisco when Eugenio (“Geno”) de Hostos picked up the phone—but when his colleagues in China answered, he felt the familiar jolt of excitement. He’d felt the same thrill at dawn, talking to his colleagues in Switzerland. At five, in a call to Maryland with the US Food and […] ; ; ; ;Related StoriesWaking from sleeping sickness in the DRCThe surprising consequences of tuberculosisPATH is at SXSW ;

Insecticidal Paints: A Realistic Approach to Vector Control?

by Karin L. Schiøler, Michael Alifrangis, Uriel Kitron, Flemming Konradsen

News in the Humanosphere: Angola suffers worst Yellow Fever outbreak in 30 years

Angola is grappling with a yellow fever outbreak, which has infected more than 450 people and killed 178 – the first epidemic of the disease to hit the country in 30 years. The outbreak, which was first reported in the capital city Luanda in December 2015, has since spread to 6 of the country’s 18

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A prospective cohort study of the effectiveness of the primary hospital management of all…

by Seyed Shahmy, Senanayake A. M.


Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in…

by Justin Windingoudi Kaboré, Hamidou Ilboudo, Harry Noyes, Oumou Camara, Jacques Kaboré, Mamadou Camara, Mathurin Koffi, Veerle Lejon, Vincent Jamonneau, Annette MacLeod, Christiane Hertz-Fowler, Adrien Marie Gaston Belem, Enock Matovu, Bruno Bucheton, Issa Sidibe, for the TrypanoGEN Research Group as members of The H3Africa Consortium Background Human African trypanosomiasis (HAT), a lethal disease induced by Trypanosoma brucei gambiense, has a range of clinical outcomes in its human host in West Africa: an acute form progressing rapidly to second stage, spontaneous self-cure and individuals able to regulate parasitaemia at very low levels, have all been reported from endemic foci. In order to test if this clinical diversity is influenced by host genetic determinants, the association between candidate gene polymorphisms and HAT outcome was investigated in populations from HAT active foci in Guinea. Methodology and results Samples were collected from 425 individuals; comprising of 232 HAT cases, 79 subjects with long lasting positive and specific serology but negative parasitology and 114 endemic controls


Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via…

by Justin Komguep Nono, Hlumani Ndlovu, Nada Abdel Aziz, Thabo Mpotje, Lerato Hlaka, Frank Brombacher Interleukin-4 receptor (IL-4Rα) is critical for the initiation of type-2 immune responses and implicated in the pathogenesis of experimental schistosomiasis. IL-4Rα mediated type-2 responses are critical for the control of pathology during acute schistosomiasis. However, type-2 responses tightly associate with fibrogranulomatous inflammation that drives host pathology during chronic schistosomiasis.


Vector competence of populations of <i>Aedes aegypti</i> from three distinct cities…

by Sheila B. Agha, Edith Chepkorir, Francis Mulwa, Caroline Tigoi, Samwel Arum, Milehna M.


Expression of interferon-inducible chemokines and sleep/wake changes during early encephalitis…

by Claudia Laperchia, Chiara Tesoriero, Paul F. Seke-Etet, Valentina La Verde, Valeria Colavito, Gigliola Grassi-Zucconi, Jean Rodgers, Paul Montague, Peter G.


Correlation between mosquito larval density and their habitat physicochemical characteristics…

by Seyed Hassan Nikookar, Mahmoud Fazeli-Dinan, Shahyad Azari-Hamidian, Seyed Nouraddin Mousavinasab, Mohsen Aarabi, Seyyed Payman Ziapour, Yahya Esfandyari, Ahmadali Enayati Characteristics of mosquito larval habitats are important in determining whether they can survive and successfully complete their developmental stages. Therefore, data on the ecological factors affecting mosquito density and abundance especially the physicochemical properties of water of their breeding sites, can possibly be helpful in implementing larval management programs. Mosquito larvae were collected using a standard 350 ml dipper from fixed habitats including: artificial pool, river edge, creek and etc, in 30 villages of 16 counties from May-December 2014


The location of Australian Buruli ulcer lesions—Implications for unravelling disease…

by Arvind Yerramilli, Ee Laine Tay, Andrew J. Stewardson, Peter G. Kelley, Emma Bishop, Grant A.


A strategy for scaling up access to comprehensive care in adults with Chagas disease in endemic…

by Maria-Jesus Pinazo, Jimy Pinto, Lourdes Ortiz, Jareth Sánchez, Wilson García, Ruth Saravia, Mirko-R Cortez, Silvia Moriana, Enric Grau, Daniel Lozano, Joaquim Gascon, Faustino Torrico Background Bolivia has the highest prevalence of Chagas disease (CD) in the world (6.1%), with more than 607,186 people with Trypanosoma cruzi infection, most of them adults. In Bolivia CD has been declared a national priority. In 2009, the Chagas National Program (ChNP) had neither a protocol nor a clear directive for diagnosis and treatment of adults.


Persistent infection due to a small-colony variant of <i>Burkholderia…

by Jia-Xiang See, Samudi Chandramathi, Mahmood Ameen Abdulla, Jamuna Vadivelu, Esaki M. Shankar Background Melioidosis is a neglected tropical disease endemic across South East Asia and Northern Australia.


Increased hepatotoxicity among HIV-infected adults co-infected with <i>Schistosoma…

by Amon I. Marti, Soledad Colombe, Peter J. Masikini, Samuel E.


Assessment of risk of dengue and yellow fever virus transmission in three major Kenyan cities…

by Sheila B. Agha, David P. Tchouassi, Armanda D.


An enduring legacy of discovery: Margaret Stirewalt

by Lucie Henein, James J. Cody, Michael H.


Caprine brucellosis: A historically neglected disease with significant impact on public health

by Carlos A. Rossetti, Angela M.


Adherence to ivermectin is more associated with perceptions of community directed treatment…

by Fanny Nadia Dissak-Delon, Guy-Roger Kamga, Perrine Claire Humblet, Annie Robert, Jacob Souopgui, Joseph Kamgno, Marie José Essi, Stephen Mbigha Ghogomu, Isabelle Godin Background The fight against onchocerciasis in Africa has boomed thanks to the Community Directed Treatment with Ivermectin (CDTI) program. However, in Cameroon, after more than 15 years of mass treatment, onchocerciasis prevalence is still above the non-transmission threshold. This study aimed to explore a possible association between people’s beliefs/perceptions of onchocerciasis and of CDTI program, and their adherence to ivermectin in three regions of Cameroon


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