Neglected Tropical Diseases

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Insecticidal Paints: A Realistic Approach to Vector Control?

by Karin L. Schiøler, Michael Alifrangis, Uriel Kitron, Flemming Konradsen

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News in the Humanosphere: Angola suffers worst Yellow Fever outbreak in 30 years

Angola is grappling with a yellow fever outbreak, which has infected more than 450 people and killed 178 – the first epidemic of the disease to hit the country in 30 years. The outbreak, which was first reported in the capital city Luanda in December 2015, has since spread to 6 of the country’s 18

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View on Poverty: Rift Valley fever fight is flawed

Unexplained meat bans can alienate people and hurt livelihoods. Salome Bukachi proposes ways to improve response.

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Zika in the United States of America and a Fateful 1969 Decision

by Peter J. Hotez The United States Gulf Coast’s current risk to Zika transmitted by Aedes aegypti mosquitoes can be traced back to some important federal health policy decisions made during the 1960s.


Projected Impact of Dengue Vaccination in Yucatán, Mexico

by Thomas J. Hladish, Carl A.


Quantifying the Epidemiological Impact of Vector Control on Dengue

by Robert C. Reiner Jr., Nicole Achee, Roberto Barrera, Thomas R. Burkot, Dave D


Old World Cutaneous Leishmaniasis and Refugee Crises in the Middle East and North Africa

by Rebecca Du, Peter J. Hotez, Waleed S.


Eggs as a Suitable Tool for Species Diagnosis of Causative Agents of Human Diphyllobothriosis…

by Kateřina Leštinová, Miroslava Soldánová, Tomáš Scholz, Roman Kuchta Background Tapeworms of the order Diphyllobothriidea are parasites of tetrapods and several species may infect man and cause neglected human disease called diphyllobothriosis. Identification of human-infecting diphyllobothriid cestodes is difficult because of their morphological uniformity, which concerns also their eggs in stool samples.


Research Capacity Strengthening in Low and Middle Income Countries – An Evaluation of the…

by Michael Käser, Christine Maure, Beatrice M. M.


Temporal Dynamics and Spatial Patterns of Aedes aegypti. Breeding Sites, in…

by Manuel Espinosa, Diego Weinberg, Camilo H. Rotela, Francisco Polop, Marcelo Abril, Carlos Marcelo Scavuzzo Background Since 2009, Fundación Mundo Sano has implemented an Aedes aegypti Surveillance and Control Program in Tartagal city (Salta Province, Argentina). The purpose of this study was to analyze temporal dynamics of Ae.


Recombinant Forms of Leishmania amazonensis. Excreted/Secreted Promastigote…

by Elodie Petitdidier, Julie Pagniez, Gérard Papierok, Philippe Vincendeau, Jean-Loup Lemesre, Rachel Bras-Gonçalves Preventive vaccination is a highly promising strategy for interrupting leishmaniasis transmission that can, additionally, contribute to elimination. A vaccine formulation based on naturally excreted secreted (ES) antigens was prepared from L. infantum promastigote culture supernatant.


Correction: Validation of qPCR Methods for the Detection of <i>Mycobacterium</i> in…

by Genevieve Housman, Joanna Malukiewicz, Vanner Boere, Adriana D. Grativol, Luiz Cezar M.


Immunohistochemical Analysis of Scarring Trachoma Indicates Infiltration by Natural Killer and…

by Victor H. Hu, Philip J.


The Burden of <i>Cryptosporidium</i> Diarrheal Disease among Children < 24…

by Samba O. Sow, Khitam Muhsen, Dilruba Nasrin, William C.


Pauci- and Multibacillary Leprosy: Two Distinct, Genetically Neglected Diseases

by Jean Gaschignard, Audrey Virginia Grant, Nguyen Van Thuc, Marianna Orlova, Aurélie Cobat, Nguyen Thu Huong, Nguyen Ngoc Ba, Vu Hong Thai, Laurent Abel, Erwin Schurr, Alexandre Alcaïs After sustained exposure to Mycobacterium leprae, only a subset of exposed individuals develops clinical leprosy. Moreover, leprosy patients show a wide spectrum of clinical manifestations that extend from the paucibacillary (PB) to the multibacillary (MB) form of the disease. This “polarization” of leprosy has long been a major focus of investigation for immunologists because of the different immune response in these two forms.


Early Transcriptional Signatures of the Immune Response to a Live Attenuated Tetravalent Dengue…

by Fiona R. Strouts, Stephen J.


Cholesterol Corrects Altered Conformation of MHC-II Protein in Leishmania…

by Koushik Roy, Sapan Mandloi, Saikat Chakrabarti, Syamal Roy Background Previously we reported that Kala-azar patients show progressive decrease in serum cholesterol as a function of splenic parasite burden. Splenic macrophages (MΦ) of Leishmania donovani (LD) infected mice show decrease in membrane cholesterol, while LD infected macrophages (I-MΦ) show defective T cell stimulating ability that could be corrected by liposomal delivery of cholesterol. T helper cells recognize peptide antigen in the context of class II MHC molecule.


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