Neglected Tropical Diseases

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Doing Today’s Work Superbly Well — Treating Ebola with Current Tools — NEJM

Doing Today’s Work Superbly Well — Treating Ebola with Current Tools — NEJM.

Cynthia GoldsmithThis colorized transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by an Ebola virus virion. See PHIL 1832 for a black and white version of this image.Where is Ebola virus found in nature?The exact origin, locations, and natural habitat (known as the "natural reservoir") of Ebola virus remain unknown. However, on the basis of available evidence and the nature of similar viruses, researchers believe that the virus is zoonotic (animal-borne) and is normally maintained in an animal host that is native to the African continent. A similar host is probably associated with Ebola-Reston which was isolated from infected cynomolgous monkeys that were imported to the United States and Italy from the Philippines. The virus is not known to be native to other continents, such as North America.

A virologist in the hot zone

Science/AAAS | Q & A with Virologist Heinz Feldmann, who co-developed one of the Ebola vaccine candidates and recently visited Monrovia, Liberia, to work in Read More

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Sierra Leone: Ebola hospital staff walk out due to lack of pay

September 16, 2014 Health workers walked out of an Ebola ward in a district hospital

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Where the Road Ends, Yaws Begins? The Cost-effectiveness of Eradication versus More Roads

by Christopher Fitzpatrick, Kingsley Asiedu, Jean Jannin Introduction A disabling and disfiguring disease that “begins where the road ends”, yaws is targeted by WHO for eradication by the year 2020. The global campaign is not yet financed. To evaluate yaws eradication within the context of the post-2015 development agenda, we perform a somewhat allegorical cost-effectiveness analysis of eradication, comparing it to a counterfactual in which we simply wait for more roads (the end of poverty)


Cathepsin B in Antigen-Presenting Cells Controls Mediators of the Th1 Immune Response during…

by Iris J. Gonzalez-Leal, Bianca Röger, Angela Schwarz, Tanja Schirmeister, Thomas Reinheckel, Manfred B. Lutz, Heidrun Moll Resistance and susceptibility to Leishmania major infection in the murine model is determined by the capacity of the host to mount either a protective Th1 response or a Th2 response associated with disease progression


Dynamics of Japanese Encephalitis Virus Transmission among Pigs in Northwest Bangladesh and the…

by Salah Uddin Khan, Henrik Salje, A. Hannan, Md.


Evaluation of Biochemical, Hematological and Parasitological Parameters of Protein-Deficient…

by Carina P. Pacanaro, Sílvia R.


Public Awareness and Knowledge of Neglected Tropical Diseases (NTDs) Control Activities in…

by Olatunwa J. Olamiju, Francisca O. Olamiju, Adebiyi A.


Crimean-Congo Hemorrhagic Fever Virus Clades V and VI (Europe 1 and 2) in Ticks in Kosovo, 2012

by Kurtesh Sherifi, Daniel Cadar, Skender Muji, Avni Robaj, Salih Ahmeti, Xhevat Jakupi, Petra Emmerich, Andreas Krüger Despite being a small country, Kosovo represents one of the few foci of Crimean-Congo hemorrhagic fever (CCHF) in Europe. The distribution of Kosovar tick vectors and the evolution of CCHF virus in ticks are both as yet unknown. A better description of the extent and the genetic diversity of CCHFV in ticks from endemic settings is essential, in order to be controlled.


Evaluation of the Murine Immune Response to Xenopsylla cheopis Flea Saliva and Its Effect on…

by Christopher F. Bosio, Austin K. Viall, Clayton O.


Strongyloides stercoralis: Systematic Review of Barriers to Controlling Strongyloidiasis for…

by Adrian Miller, Michelle L. Smith, Jenni A. Judd, Rick Speare Background Strongyloides stercoralis infects human hosts mainly through skin contact with contaminated soil


Impact of Leishmania mexicana Infection on Dendritic Cell Signaling and Functions

by Irazú Contreras, José A. Estrada, Hannah Guak, Caroline Martel, Alborz Borjian, Benjamin Ralph, Marina T. Shio, Sylvie Fournier, Connie M


Use of Humanised Rat Basophilic Leukaemia Cell Line RS-ATL8 for the Assessment of Allergenicity…

by Daniel Wan, Fernanda Ludolf, Daniel G. W.


Nematode-Induced Interference with Vaccination Efficacy Targets Follicular T Helper Cell…

by Irma Haben, Wiebke Hartmann, Minka Breloer One-third of the human population is infected with parasitic worms. To avoid being eliminated, these parasites actively dampen the immune response of their hosts. This immune modulation also suppresses immune responses to third-party antigens such as vaccines.


Eradication of Yaws: Historical Efforts and Achieving WHO’s 2020 Target

by Kingsley Asiedu, Christopher Fitzpatrick, Jean Jannin Background Yaws, one of the 17 neglected tropical diseases (NTDs), is targeted for eradication by 2020 in resolution WHA66.12 of the World Health Assembly (2013) and the WHO roadmap on NTDs (2012). The disease frequently affects children who live in poor socioeconomic conditions. Between 1952 and 1964, WHO and the United Nations Children’s Fund (UNICEF) led a global eradication campaign using injectable benzathine penicillin.


Strong Type 1, but Impaired Type 2, Immune Responses Contribute to Orientia…

by Lynn Soong, Hui Wang, Thomas R. Shelite, Yuejin Liang, Nicole L.


Comparison of Biotinylated Monoclonal and Polyclonal Antibodies in an Evaluation of a Direct…

by Andre Coetzer, Claude T. Sabeta, Wanda Markotter, Charles E. Rupprecht, Louis H


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