Neglected Tropical Diseases


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Is a Cholera Outbreak Preventable in Post-earthquake Nepal?

by Eric J. Nelson, Jason R. Andrews, Stacey Maples, Michele Barry, John D.


Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease — NEJM

A new study on a Dengue Vaccine from The New England Journal of Medicine demonstrates an unexplained higher incidence of hospitalization for dengue in year 3 Read More

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Poor health systems hamper fight against tropical diseases

Just US$300 million a year would greatly improve drug delivery for neglected tropical diseases, says coalition.


The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and…

by Anna Crisford, Ulrich Ebbinghaus-Kintscher, Eva Schoenhense, Achim Harder, Klaus Raming, Ita O’Kelly, Kelechi Ndukwe, Vincent O’Connor, Robert J. Walker, Lindy Holden-Dye The anthelmintic emodepside paralyses adult filarial worms, via a mode of action distinct from previous anthelmintics and has recently garnered interest as a new treatment for onchocerciasis.

A Retrospective Study on Genetic Heterogeneity within Treponema Strains: Subpopulations Are…

by Darina Čejková, Michal Strouhal, Steven J. Norris, George M. Weinstock, David Šmajs Background Pathogenic uncultivable treponemes comprise human and animal pathogens including agents of syphilis, yaws, bejel, pinta, and venereal spirochetosis in rabbits and hares.

Colonization of Lutzomyia verrucarum and Lutzomyia longipalpis Sand Flies (Diptera:…

by James M. Battisti, Phillip G.

A Lentiviral Vector Expressing Japanese Encephalitis Virus-like Particles Elicits Broad…

by Mélissanne de Wispelaere, Meret Ricklin, Philippe Souque, Marie-Pascale Frenkiel, Sylvie Paulous, Obdulio Garcìa-Nicolàs, Artur Summerfield, Pierre Charneau, Philippe Desprès Background Japanese encephalitis virus (JEV) is the major cause of viral encephalitis in Southeast Asia. Vaccination of domestic pigs has been suggested as a “one health” strategy to reduce viral disease transmission to humans. The efficiency of two lentiviral TRIP/JEV vectors expressing the JEV envelope prM and E glycoproteins at eliciting protective humoral response was assessed in a mouse model and piglets.

Urban Market Gardening and Rodent-Borne Pathogenic Leptospira in Arid Zones: A Case Study in…

by Gauthier Dobigny, Madougou Garba, Caroline Tatard, Anne Loiseau, Max Galan, Ibrahima Kadaouré, Jean-Pierre Rossi, Mathieu Picardeau, Eric Bertherat Leptospirosis essentially affects human following contact with rodent urine-contaminated water. As such, it was mainly found associated with rice culture, recreational activities and flooding.

Mexico Becomes 3rd Country In World To Eliminate Onchocerciasis

Global Network for Neglected Tropical Diseases’ “End the Neglect”: Adiós! Goodbye, oncho! Mexico joins two other countries in ending onchocerciasis in LAC Mirta Roses Periago, director emeritus of PAHO/WHO and special envoy for the Global Network, discusses progress made by the Latin American and the Caribbean (LAC) region in ending onchocerciasis, also referred to as…More

Global Burden of Leptospirosis: Estimated in Terms of Disability Adjusted Life Years

by Paul R. Torgerson, José E. Hagan, Federico Costa, Juan Calcagno, Michael Kane, Martha S.

Use of Pentamidine As Secondary Prophylaxis to Prevent Visceral Leishmaniasis Relapse in HIV…

by Ermias Diro, Koert Ritmeijer, Marleen Boelaert, Fabiana Alves, Rezika Mohammed, Charles Abongomera, Raffaella Ravinetto, Maaike De Crop, Helina Fikre, Cherinet Adera, Robert Colebunders, Harry van Loen, Joris Menten, Lutgarde Lynen, Asrat Hailu, Johan van Griensven Background Visceral leishmaniasis (VL) has become an important opportunistic infection in persons with HIV-infection in VL-endemic areas. The co-infection leads to profound immunosuppression and high rate of annual VL recurrence.

Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB)

by Rebuma Firdessa, Liam Good, Maria Cecilia Amstalden, Kantaraja Chindera, Nor Fadhilah Kamaruzzaman, Martina Schultheis, Bianca Röger, Nina Hecht, Tobias A. Oelschlaeger, Lorenz Meinel, Tessa Lühmann, Heidrun Moll Background Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania.

The Effect of Deworming on Growth in One-Year-Old Children Living in a Soil-Transmitted…

by Serene A. Joseph, Martín Casapía, Antonio Montresor, Elham Rahme, Brian J.

Classification of Rhinoentomophthoromycosis into Atypical, Early, Intermediate, and Late…

by Christian G. Blumentrath, Martin P. Grobusch, Pierre-Blaise Matsiégui, Friedrich Pahlke, Rella Zoleko-Manego, Solange Nzenze-Aféne, Barthélemy Mabicka, Maurizio Sanguinetti, Peter G

Effect of Poor Access to Water and Sanitation As Risk Factors for Soil-Transmitted Helminth…

by Adriana Echazú, Daniela Bonanno, Marisa Juarez, Silvana P. Cajal, Viviana Heredia, Silvia Caropresi, Ruben O. Cimino, Nicolas Caro, Paola A

Trends of Mycobacterium bovis Isolation and First-Line Anti-tuberculosis Drug Susceptibility…

by Miriam Bobadilla-del Valle, Pedro Torres-González, Miguel Enrique Cervera-Hernández, Areli Martínez-Gamboa, Brenda Crabtree-Ramirez, Bárbara Chávez-Mazari, Narciso Ortiz-Conchi, Luis Rodríguez-Cruz, Axel Cervantes-Sánchez, Tomasa Gudiño-Enríquez, Carmen Cinta-Severo, José Sifuentes-Osornio, Alfredo Ponce de León Background Mycobacterium tuberculosis causes the majority of tuberculosis (TB) cases in humans; however, in developing countries, human TB caused by M. bovis may be frequent but undetected. Human TB caused by M

Understanding Heterogeneity in the Impact of National Neglected Tropical Disease Control…

by Birgit Nikolay, Charles S. Mwandawiro, Jimmy H. Kihara, Collins Okoyo, Jorge Cano, Mariam T

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