Neglected Tropical Diseases

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Insecticidal Paints: A Realistic Approach to Vector Control?

by Karin L. Schiøler, Michael Alifrangis, Uriel Kitron, Flemming Konradsen

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News in the Humanosphere: Angola suffers worst Yellow Fever outbreak in 30 years

Angola is grappling with a yellow fever outbreak, which has infected more than 450 people and killed 178 – the first epidemic of the disease to hit the country in 30 years. The outbreak, which was first reported in the capital city Luanda in December 2015, has since spread to 6 of the country’s 18

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View on Poverty: Rift Valley fever fight is flawed

Unexplained meat bans can alienate people and hurt livelihoods. Salome Bukachi proposes ways to improve response.

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Hydrological Regime and Water Shortage as Drivers of the Seasonal Incidence of Diarrheal…

by Laurie Boithias, Marc Choisy, Noy Souliyaseng, Marine Jourdren, Fabrice Quet, Yves Buisson, Chanthamousone Thammahacksa, Norbert Silvera, Keooudone Latsachack, Oloth Sengtaheuanghoung, Alain Pierret, Emma Rochelle-Newall, Sylvia Becerra, Olivier Ribolzi Background The global burden of diarrhea is a leading cause of morbidity and mortality worldwide. In montane areas of South-East Asia such as northern Laos, recent changes in land use have induced increased runoff, soil erosion and in-stream suspended sediment loads, and potential pathogen dissemination.


Crystal Structure of <i>Schistosoma mansoni</i> Adenosine…

by Juliana Roberta Torini, José Brandão-Neto, Ricardo DeMarco, Humberto D’Muniz Pereira Schistosoma mansoni do not have de novo purine pathways and rely on purine salvage for their purine supply. It has been demonstrated that, unlike humans, the S. mansoni is able to produce adenine directly from adenosine, although the enzyme responsible for this activity was unknown


Emerging Infectious Disease Implications of Invasive Mammalian Species: The Greater…

by Jarlath E. Nally, Zbigniew Arent, Darrell O.


Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage…

by Paul Griffin, Cielo Pasay, Suzanne Elliott, Silvana Sekuloski, Maggy Sikulu, Leon Hugo, David Khoury, Deborah Cromer, Miles Davenport, Jetsumon Sattabongkot, Karen Ivinson, Christian Ockenhouse, James McCarthy Background Interventions to interrupt transmission of malaria from humans to mosquitoes represent an appealing approach to assist malaria elimination. A limitation has been the lack of systems to test the efficacy of such interventions before proceeding to efficacy trials in the field. We have previously demonstrated the feasibility of induced blood stage malaria (IBSM) infection with Plasmodium vivax


Oral Cholera Vaccination Delivery Cost in Low- and Middle-Income Countries: An Analysis Based…

by Vittal Mogasale, Enusa Ramani, Hyeseung Wee, Jerome H. Kim Background Use of the oral cholera vaccine (OCV) is a vital short-term strategy to control cholera in endemic areas with poor water and sanitation infrastructure. Identifying, estimating, and categorizing the delivery costs of OCV campaigns are useful in analyzing cost-effectiveness, understanding vaccine affordability, and in planning and decision making by program managers and policy makers


Isothermal Diagnostic Assays for Monitoring Single Nucleotide Polymorphisms in <i>Necator…

by Nour Rashwan, Catherine Bourguinat, Kathy Keller, Nipul Kithsiri Gunawardena, Nilanthi de Silva, Roger Prichard Background Soil-transmitted helminths (STHs) are the most prevalent intestinal helminths of humans, and a major cause of morbidity in tropical and subtropical countries. The benzimidazole (BZ) drugs albendazole (ABZ) and mebendazole (MBZ) are used for treatment of human STH infections and this use is increasing dramatically with massive drug donations. Frequent and prolonged use of these drugs could lead to the emergence of anthelmintic resistance as has occurred in nematodes of livestock.


A Historic Report of Zika in Mozambique: Implications for Assessing Current Risk

by Eduardo Samo Gudo, Kerstin I. Falk, Sadia Ali, Argentina Felisbela Muianga, Vanessa Monteiro, Julie Cliff


<i>Plasmodium vivax</i> but Not <i>Plasmodium falciparum</i>…

by Julie G. Burel, Simon H. Apte, James S


Uncovering the Pathogenic Landscape of Helminth (<i>Opisthorchis viverrini</i>)…

by Xueyuan Ong, Yi-Chen Wang, Paiboon Sithithaworn, Jutamas Namsanor, David Taylor, Luxana Laithavewat Background Helminth infections have proven recalcitrant to control by chemotherapy in many parts of Southeast Asia and indeed farther afield. This study isolates and examines the influence of different aspects of the physical and social environment, and uneven intervention effort contributing to the pathogenic landscape of human Opisthorchis viverrini infections. Methodology A cross-sectional survey, involving 632 participants, was conducted in four villages in northeast Thailand to examine the impact on prevalence and parasite burden of the reservoir dam environment, socio-economic, demographic, and behavioral factors, and health center intervention efforts.


Different Mutations in a P-type ATPase Transporter in <i>Leishmania</i> Parasites…

by Christopher Fernandez-Prada, Isabel M. Vincent, Marie-Christine Brotherton, Mathew Roberts, Gaétan Roy, Luis Rivas, Philippe Leprohon, Terry K. Smith, Marc Ouellette Leishmania infantum is an etiological agent of the life-threatening visceral form of leishmaniasis


<i>Schistosoma mansoni</i> Infection Can Jeopardize the Duration of Protective…

by Diana K. Riner, Eric M. Ndombi, Jennifer M.


Public Health Interventions for <i>Aedes</i> Control in the Time of Zikavirus– A…

by Maha Bouzid, Julii Brainard, Lee Hooper, Paul R. Hunter Background There is renewed interest in effective measures to control Zika and dengue vectors. A synthesis of published literature with a focus on the quality of evidence is warranted to determine the effectiveness of vector control strategies.


Implementation of Syndromic Surveillance Systems in Two Rural Villages in Senegal

by Cédric Abat, Philippe Colson, Hervé Chaudet, Jean-Marc Rolain, Hubert Bassene, Aldiouma Diallo, Oleg Mediannikov, Florence Fenollar, Didier Raoult, Cheikh Sokhna Infectious diseases still represent a major challenge for humanity. In this context, their surveillance is critical.


Evaluation of Lymphatic Filariasis and Onchocerciasis in Three Senegalese Districts Treated for…

by Nana O. Wilson, Alioune Badara Ly, Vitaliano A. Cama, Paul T.


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