Neglected Tropical Diseases

Featured

Insecticidal Paints: A Realistic Approach to Vector Control?

by Karin L. Schiøler, Michael Alifrangis, Uriel Kitron, Flemming Konradsen

News in the Humanosphere: Angola suffers worst Yellow Fever outbreak in 30 years

Angola is grappling with a yellow fever outbreak, which has infected more than 450 people and killed 178 – the first epidemic of the disease to hit the country in 30 years. The outbreak, which was first reported in the capital city Luanda in December 2015, has since spread to 6 of the country’s 18

View on Poverty: Rift Valley fever fight is flawed

Unexplained meat bans can alienate people and hurt livelihoods. Salome Bukachi proposes ways to improve response.

Latest

Endomyocardial involvement in asymptomatic sub-Saharan immigrants with helminth-related…

by Cristina Carranza-Rodríguez, Daniel San-Román-Sánchez, Héctor Marrero-Santiago, Michele Hernández-Cabrera, Carlos Gil-Guillén, Elena Pisos-Álamo, Nieves Jaén-Sánchez, José-Luis Pérez-Arellano Background Among immigrants of sub-Saharan origin, parasitic infection is the leading cause of eosinophilia, which is generally interpreted as a defense mechanism. A side effect of the inflammatory mediators released by eosinophils is damage to host organs, especially the heart. The main objectives of this study were to i) assess cardiac involvement in asymptomatic sub-Saharan immigrants with eosinophilia, ii) relate the presence of lesions with the degree of eosinophilia, and iii) study the relationship between cardiac involvement and the type of causative parasite.


Experimental infection and transmission of <i>Leishmania</i> by <i>Lutzomyia…

by Everton Falcão de Oliveira, Elisa Teruya Oshiro, Wagner Souza Fernandes, Paula Guerra Murat, Márcio José de Medeiros, Alda Izabel Souza, Alessandra Gutierrez de Oliveira, Eunice Aparecida Bianchi Galati Several parameters should be addressed before incriminating a vector for Leishmania transmission. Those may include its ability to become infected by the same Leishmania species found in humans, the degree of attractiveness for reservoirs and humans and capacity to sustain parasite infection under laboratory conditions.


Immunization with Tc52 or its amino terminal domain adjuvanted with c-di-AMP induces Th17+Th1…

by Marina N. Matos, Silvia I. Cazorla, Kai Schulze, Thomas Ebensen, Carlos A


Intensive trapping of blood-fed <i>Anopheles darlingi</i> in Amazonian Peru reveals…

by Marta Moreno, Marlon P. Saavedra, Sara A. Bickersmith, Catharine Prussing, Adrian Michalski, Carlos Tong Rios, Joseph M


Global urbanization and the neglected tropical diseases

by Peter J. Hotez


Product development programs for neglected tropical diseases: A crucial role for expert…

by Leonie Hussaarts, Kim van der Weijde, Pierre Dome, Elly Kourany-Lefoll, Jutta Reinhard-Rupp, Remco de Vrueh, on behalf of the Pediatric Praziquantel Consortium


Galectin-3, histone deacetylases, and Hedgehog signaling: Possible convergent targets in…

by Felipe Leite de Oliveira, Katia Carneiro, José Marques Brito, Mariana Cabanel, Jonathas Xavier Pereira, Ligia de Almeida Paiva, Wingkin Syn, Neil C. Henderson, Marcia Cury El-Cheikh Schistosomiasis affects approximately 240 million people in the world.


Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals…

by Thi Huyen Tram Nguyen, Jérémie Guedj, Xavier Anglaret, Cédric Laouénan, Vincent Madelain, Anne-Marie Taburet, Sylvain Baize, Daouda Sissoko, Boris Pastorino, Anne Rodallec, Géraldine Piorkowski, Sara Carazo, Mamoudou N. Conde, Jean-Luc Gala, Joseph Akoi Bore, Caroline Carbonnelle, Frédéric Jacquot, Hervé Raoul, Denis Malvy, Xavier de Lamballerie, France Mentré, JIKI study group Background In 2014–2015, we assessed favipiravir tolerance and efficacy in patients with Ebola virus (EBOV) disease (EVD) in Guinea (JIKI trial). Because the drug had never been used before for this indication and that high concentrations of the drugs were needed to achieve antiviral efficacy against EBOV, a pharmacokinetic model had been used to propose relevant dosing regimen


Unexpectedly high leprosy seroprevalence detected using a random surveillance strategy in…

by Marco Andrey C. Frade, Natália A.


Hydrocephalus and arthrogryposis in an immunocompetent mouse model of ZIKA teratogeny: A…

by Jose Xavier-Neto, Murilo Carvalho, Bruno dos Santos Pascoalino, Alisson Campos Cardoso, Ângela Maria Sousa Costa, Ana Helena Macedo Pereira, Luana Nunes Santos, Ângela Saito, Rafael Elias Marques, Juliana Helena Costa Smetana, Silvio Roberto Consonni, Carla Bandeira, Vivian Vasconcelos Costa, Marcio Chaim Bajgelman, Paulo Sérgio Lopes de Oliveira, Marli Tenorio Cordeiro, Laura Helena Vega Gonzales Gil, Bianca Alves Pauletti, Daniela Campos Granato, Adriana Franco Paes Leme, Lucio Freitas-Junior, Carolina Borsoi Moraes Holanda de Freitas, Mauro Martins Teixeira, Estela Bevilacqua, Kleber Franchini The teratogenic mechanisms triggered by ZIKV are still obscure due to the lack of a suitable animal model. Here we present a mouse model of developmental disruption induced by ZIKV hematogenic infection. The model utilizes immunocompetent animals from wild-type FVB/NJ and C57BL/6J strains, providing a better analogy to the human condition than approaches involving immunodeficient, genetically modified animals, or direct ZIKV injection into the brain


Predicting Ebola infection: A malaria-sensitive triage score for Ebola virus disease

by Mary-Anne Hartley, Alyssa Young, Anh-Minh Tran, Harry Henry Okoni-Williams, Mohamed Suma, Brooke Mancuso, Ahmed Al-Dikhari, Mohamed Faouzi Background The non-specific symptoms of Ebola Virus Disease (EVD) pose a major problem to triage and isolation efforts at Ebola Treatment Centres (ETCs). Under the current triage protocol, half the patients allocated to high-risk “probable” wards were EVD(-): a misclassification speculated to predispose nosocomial EVD infection.


Cynomolgus macaques naturally infected with <i>Trypanosoma cruzi</i>-I exhibit an…

by Danielle Marquete Vitelli-Avelar, Renato Sathler-Avelar, Armanda Moreira Mattoso-Barbosa, Nicolas Gouin, Marcelo Perdigão-de-Oliveira, Leydiane Valério-dos-Reis, Ronaldo Peres Costa, Silvana Maria Elói-Santos, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Edward J. Dick Jr., Gene B. Hubbard, Jane F


Cytotoxic effector functions of T cells are not required for protective immunity against fatal…

by Kristin Moderzynski, Liza Heine, Jessica Rauch, Stefanie Papp, Svenja Kuehl, Ulricke Richardt, Bernhard Fleischer, Anke Osterloh Endemic typhus caused by Rickettsia (R.) typhi is an emerging febrile disease that can be fatal due to multiple organ pathology. Here we analyzed the requirements for protection against R. typhi by T cells in the CB17 SCID model of infection


Ultrasonographic evaluation of urinary tract morbidity in school-aged and preschool-aged…

by Beatrice Barda, Jean T. Coulibaly, Christoph Hatz, Jennifer Keiser Background Schistosoma haematobium infections are responsible for significant urinary tract (UT) complications. Schistosomiasis control programs aim to reduce morbidity, yet the extent of morbidity in preschool-aged children and the impact of treatment on morbidity reduction are not well studied.


Older Posts »