Neglected Tropical Diseases

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Is a Cholera Outbreak Preventable in Post-earthquake Nepal?

by Eric J. Nelson, Jason R. Andrews, Stacey Maples, Michele Barry, John D.

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Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease — NEJM

A new study on a Dengue Vaccine from The New England Journal of Medicine demonstrates an unexplained higher incidence of hospitalization for dengue in year 3 Read More

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Poor health systems hamper fight against tropical diseases

Just US$300 million a year would greatly improve drug delivery for neglected tropical diseases, says coalition.

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The Diversity and Geographical Structure of Orientia tsutsugamushi Strains from Scrub Typhus…

by Rattanaphone Phetsouvanh, Piengchan Sonthayanon, Sasithon Pukrittayakamee, Daniel H. Paris, Paul N. Newton, Edward J


Improved Quantification, Propagation, Purification and Storage of the Obligate Intracellular…

by Suparat Giengkam, Alex Blakes, Peemdej Utsahajit, Suwittra Chaemchuen, Sharanjeet Atwal, Stuart D. Blacksell, Daniel H. Paris, Nicholas P.


rPbPga1 from Paracoccidioides brasiliensis Activates Mast Cells and Macrophages via NFkB

by Clarissa Xavier Resende Valim, Elaine Zayas Marcelino da Silva, Mariana Aprigio Assis, Fabricio Freitas Fernandes, Paulo Sergio Rodrigues Coelho, Constance Oliver, Maria Célia Jamur Background The fungus Paracoccidioides brasiliensis is the leading etiological agent of paracoccidioidomycosis (PCM), a systemic granulomatous disease that typically affects the lungs. Cell wall components of P. brasiliensis interact with host cells and influence the pathogenesis of PCM


Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with…

by Daniel H. Paris, Femke Stephan, Ingrid Bulder, Diana Wouters, Tom van der Poll, Paul N. Newton, Nicholas P.


Bile Salts Modulate the Mucin-Activated Type VI Secretion System of Pandemic Vibrio cholerae

by Verena Bachmann, Benjamin Kostiuk, Daniel Unterweger, Laura Diaz-Satizabal, Stephen Ogg, Stefan Pukatzki The causative agent of cholera, Vibrio cholerae, regulates its diverse virulence factors to thrive in the human small intestine and environmental reservoirs. Among this pathogen’s arsenal of virulence factors is the tightly regulated type VI secretion system (T6SS). This system acts as an inverted bacteriophage to inject toxins into competing bacteria and eukaryotic phagocytes


WHO Promotes WASH As Strategy To Prevent NTDs

News outlets report on the WHO’s new global strategy to prevent neglected tropical diseases through improved access to water, sanitation, and hygiene. Reuters: WHO promotes water, sanitation to battle neglected tropical diseases “Water, sanitation, and hygiene are part of a new World Health Organization strategy to fight neglected tropical diseases which afflict more than 1.5…More


Immunogenicity and Serological Cross-Reactivity of Saliva Proteins among Different Tsetse…

by Xin Zhao, Thiago Luiz Alves e Silva, Laura Cronin, Amy F. Savage, Michelle O’Neill, Barbara Nerima, Loyce M. Okedi, Serap Aksoy Tsetse are vectors of pathogenic trypanosomes, agents of human and animal trypanosomiasis in Africa.


Building Research and Development Capacity for Neglected Tropical Diseases Impacting…

by Sima Rafati, Shaden Kamhawi, Jesus G. Valenzuela, Mostafa Ghanei


Involvement of PSMD10, CDK4, and Tumor Suppressors in Development of Intrahepatic…

by Md. Hafiz Uddin, Min-Ho Choi, Woo Ho Kim, Ja-June Jang, Sung-Tae Hong Background Clonorchis sinensis is a group-I bio-carcinogen for cholangiocarcinoma (CCA). Although the epidemiological evidence links clonorchiasis and CCA, the underlying molecular mechanism involved in this process is poorly understood.


Ecological Model to Predict Potential Habitats of Oncomelania hupensis, the Intermediate Host…

by Hong-Ru Zhu, Lu Liu, Xiao-Nong Zhou, Guo-Jing Yang Background Schistosomiasis japonica is a parasitic disease that remains endemic in seven provinces in the People’s Republic of China (P.R. China). One of the most important measures in the process of schistosomiasis elimination in P.R


Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the…

by Néstor A. Guerrero, Mercedes Camacho, Luis Vila, Miguel A. Íñiguez, Carlos Chillón-Marinas, Henar Cuervo, Cristina Poveda, Manuel Fresno, Núria Gironès Inflammation plays an important role in the pathophysiology of Chagas disease, caused by Trypanosoma cruzi.


Proteomics-Based Characterization of the Humoral Immune Response in Sporotrichosis: Toward…

by Anderson Messias Rodrigues, Geisa Ferreira Fernandes, Leticia Mendes Araujo, Paula Portella Della Terra, Priscila Oliveira dos Santos, Sandro Antonio Pereira, Tânia Maria Pacheco Schubach, Eva Burger, Leila Maria Lopes-Bezerra, Zoilo Pires de Camargo Background Sporothrix schenckii and associated species are agents of human and animal sporotrichosis that cause large sapronoses and zoonoses worldwide. Epidemiological surveillance has highlighted an overwhelming occurrence of the highly pathogenic fungus Sporothrix brasiliensis during feline outbreaks, leading to massive transmissions to humans.


Case Report: No Response to Liposomal Daunorubicin in a Patient with Drug-Resistant…

by Nicholas J. Gow, Robert N.


The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription…

by David Roquis, Julie M. J. Lepesant, Marion A.


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