Neglected Tropical Diseases



Guinea Worm, Inching Toward Eradication

By Bill Brieger: “Twenty-eight years ago efforts to eradicate guinea worm began in earnest.  It was the UN Water Decade, and there was optimism that Read More

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The World Health Assembly

Dear Colleagues, This week Remco van de Pas flew back and forth between the Netherlands (European elections), Antwerp (ITM) and Geneva (World Health Assembly), and he mailed me it’s been a gruelling week. Read below some of his first comments on the WHA, or ‘The World Health Theatre’, as he calls it.  More might follow early next week. … And finally it has arrived, The World Health Assembly in Geneva! This is something of an annual ritual for me.


Myanmar’s moment: reaching millions to improve health

By Neeraj Mistry, managing director of the Global Network for Neglected Tropical Diseases Myanmar’s democratic transition and peace and reconciliation process offer the country a unique opportunity Read More


Dengue and the World Football Cup: A Matter of Timing

by Christovam Barcellos, Rachel Lowe

Transmission and Control of Plasmodium knowlesi: A Mathematical Modelling Study

by Natsuko Imai, Michael T. White, Azra C. Ghani, Chris J.

Serological, Molecular and Entomological Surveillance Demonstrates Widespread Circulation of…

by Koray Ergunay, Filiz Gunay, Ozge Erisoz Kasap, Kerem Oter, Sepandar Gargari, Taner Karaoglu, Seda Tezcan, Mehmet Cabalar, Yakup Yildirim, Gürol Emekdas, Bulent Alten, Aykut Ozkul West Nile virus (WNV), a mosquito-borne flavivirus with significant impact on human and animal health, has recently demonstrated an expanded zone of activity globally. The aim of this study is to investigate the frequency and distribution of WNV infections in potential vectors and several mammal and avian species in Turkey, where previous data indicate viral circulation.

The Population Structure of Vibrio cholerae from the Chandigarh Region of Northern India

by Moataz Abd El Ghany, Jagadish Chander, Ankur Mutreja, Mamoon Rashid, Grant A. Hill-Cawthorne, Shahjahan Ali, Raeece Naeem, Nicholas R.

The Incidence of Japanese Encephalitis in Taiwan—A Population-Based Study

by Li-Ching Hsu, Yu-Ju Chen, Feng-Kuang Hsu, Jyh-Hsiung Huang, Chi-Ming Chang, Pesus Chou, I-Feng Lin, Feng-Yee Chang Background A mass Japanese encephalitis (JE) vaccination program targeting children was launched in Taiwan in 1968, and the number of pediatric JE cases substantially decreased thereafter. The aim of this study was to elucidate the long-term trend of JE incidence, and to investigate the age-specific seroprevalence of JE-neutralizing antibodies.

Risk Factors for Adverse Prognosis and Death in American Visceral Leishmaniasis: A…

by Vinícius Silva Belo, Claudio José Struchiner, David Soeiro Barbosa, Bruno Warlley Leandro Nascimento, Marco Aurélio Pereira Horta, Eduardo Sérgio da Silva, Guilherme Loureiro Werneck Background In the current context of high fatality rates associated with American visceral leishmaniasis (VL), the appropriate use of prognostic factors to identify patients at higher risk of unfavorable outcomes represents a potential tool for clinical practice. This systematic review brings together information reported in studies conducted in Latin America, on the potential predictors of adverse prognosis (continued evolution of the initial clinical conditions of the patient despite the implementation of treatment, independent of the occurrence of death) and death from VL. The limitations of the existing knowledge, the advances achieved and the approaches to be used in future research are presented

Ocular Pentastomiasis in the Democratic Republic of the Congo

by Mihály Sulyok, Lajos Rózsa, Imre Bodó, Dennis Tappe, Richard Hardi Ocular pentastomiasis is a rare infection caused by the larval stage of pentastomids, an unusual group of crustacean-related parasites. Zoonotic pentastomids have a distinct geographical distribution and utilize reptiles or canids as final hosts. Recently, an increasing number of human abdominal infections have been reported in Africa, where pentastomiasis is an emerging, though severely neglected, tropical disease.

MALDI-TOF Mass Spectrometry Detection of Pathogens in Vectors: The Borrelia…

by Aurélien Fotso Fotso, Oleg Mediannikov, Georges Diatta, Lionel Almeras, Christophe Flaudrops, Philippe Parola, Michel Drancourt Background In Africa, relapsing fever borreliae are neglected vector-borne pathogens that cause mild to deadly septicemia and miscarriage. Screening vectors for the presence of borreliae currently requires technically demanding, time- and resource-consuming molecular methods. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has recently emerged as a tool for the rapid identification of vectors and the identification of cultured borreliae

Burden of Diarrhea, Hospitalization and Mortality Due to Cryptosporidial Infections in Indian…

by Rajiv Sarkar, Jacqueline E. Tate, Sitara S. R

Risk Factors and Spatial Distribution of Schistosoma mansoni Infection among Primary School…

by Sachiyo Nagi, Evans A. Chadeka, Toshihiko Sunahara, Faith Mutungi, Yombo K. Dan Justin, Satoshi Kaneko, Yoshio Ichinose, Sohkichi Matsumoto, Sammy M

Monitoring Antigenic Variations of Enterovirus 71: Implications for Virus Surveillance and…

by Min-Yuan Chia, Wan-Yu Chung, Pai-Shan Chiang, Yeh-Sheng Chien, Mei-Shang Ho, Min-Shi Lee Enterovirus 71 (EV71) causes life-threatening epidemics in Asia and can be phylogenetically classified into three major genogroups (A∼C) including 11 genotypes (A, B1∼B5, and C1∼C5). Recently, EV71 epidemics occurred cyclically in Taiwan with different genotypes. In recent years, human studies using post-infection sera obtained from children have detected antigenic variations among different EV71 strains.

Cross-sectional Study of the Burden of Vector-Borne and Soil-Transmitted Polyparasitism in…

by Donal Bisanzio, Francis Mutuku, Amaya L. Bustinduy, Peter L.

IrSPI, a Tick Serine Protease Inhibitor Involved in Tick Feeding and Bartonella henselae…

by Xiang Ye Liu, Jose de la Fuente, Martine Cote, Ruth C. Galindo, Sara Moutailler, Muriel Vayssier-Taussat, Sarah I. Bonnet Ixodes ricinus is the most widespread and abundant tick in Europe, frequently bites humans, and is the vector of several pathogens including those responsible for Lyme disease, Tick-Borne Encephalitis, anaplasmosis, babesiosis and bartonellosis.

Characterization of Aedes aegypti Innate-Immune Pathways that Limit Chikungunya Virus…

by Melanie McFarlane, Camilo Arias-Goeta, Estelle Martin, Zoe O’Hara, Aleksei Lulla, Laurence Mousson, Stephanie M. Rainey, Suzana Misbah, Esther Schnettler, Claire L. Donald, Andres Merits, Alain Kohl, Anna-Bella Failloux Replication of arboviruses in their arthropod vectors is controlled by innate immune responses

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