Neglected Tropical Diseases

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Meet the amazing cast behind a life-changing drug

It was well after midnight in San Francisco when Eugenio (“Geno”) de Hostos picked up the phone—but when his colleagues in China answered, he felt the familiar jolt of excitement. He’d felt the same thrill at dawn, talking to his colleagues in Switzerland. At five, in a call to Maryland with the US Food and […] ; ; ; ;Related StoriesWaking from sleeping sickness in the DRCThe surprising consequences of tuberculosisPATH is at SXSW ;

Insecticidal Paints: A Realistic Approach to Vector Control?

by Karin L. Schiøler, Michael Alifrangis, Uriel Kitron, Flemming Konradsen

News in the Humanosphere: Angola suffers worst Yellow Fever outbreak in 30 years

Angola is grappling with a yellow fever outbreak, which has infected more than 450 people and killed 178 – the first epidemic of the disease to hit the country in 30 years. The outbreak, which was first reported in the capital city Luanda in December 2015, has since spread to 6 of the country’s 18

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Clinico-pathological features of erythema nodosum leprosum: A case-control study at ALERT…

by Edessa Negera, Stephen L. Walker, Selfu Girma, Shimelis N. Doni, Degafe Tsegaye, Saba M.


Modeling the environmental suitability of anthrax in Ghana and estimating populations at risk:…

by Ian T. Kracalik, Ernest Kenu, Evans Nsoh Ayamdooh, Emmanuel Allegye-Cudjoe, Paul Nokuma Polkuu, Joseph Asamoah Frimpong, Kofi Mensah Nyarko, William A. Bower, Rita Traxler, Jason K


Human cellular and humoral immune responses to <i>Phlebotomus papatasi</i> salivary…

by Wafa Kammoun-Rebai, Narges Bahi-Jaber, Ikbel Naouar, Amine Toumi, Afif Ben Salah, Hechmi Louzir, Amel Meddeb-Garnaoui Background Sand fly saliva compounds are able to elicit specific immune responses that have a significant role in Leishmania parasite establishment and disease outcome. Characterizing anti-saliva immune responses in individuals living in well defined leishmaniasis endemic areas would provide valuable insights regarding their effect on parasite transmission and establishment in humans. Methodology/Principal findings We explored the cellular and humoral immune responses to Phlebotomus (P.) papatasi salivary gland extracts (SGE) in individuals living in cutaneous leishmaniasis (CL) old or emerging foci (OF, EF).


Towards elimination of visceral leishmaniasis in the Indian subcontinent—Translating research…

by Siddhivinayak Hirve, Axel Kroeger, Greg Matlashewski, Dinesh Mondal, Megha Raj Banjara, Pradeep Das, Ahmed Be-Nazir, Byron Arana, Piero Olliaro Background The decade following the Regional Strategic Framework for Visceral Leishmaniasis (VL) elimination in 2005 has shown compelling progress in the reduction of VL burden in the Indian subcontinent. The Special Programme for Research and Training in Tropical Diseases (TDR), hosted by the World Health Organization (WHO) and other stakeholders, has coordinated and financed research for the development of new innovative tools and strategies to support the regional VL elimination initiative. This paper describes the process of the TDR’s engagement and contribution to this initiative


Is mass drug administration against lymphatic filariasis required in urban settings? The…

by Dung D. Pam, Dziedzom K. de Souza, Susan Walker, Millicent Opoku, Safiya Sanda, Ibrahim Nazaradeen, Ifeoma N


Human macrophages differentiated in the presence of vitamin D<sub>3</sub> restrict…

by John F. Arboleda Alzate, Izabela A.


Characterization of the catalytic center of the Ebola virus L polymerase

by Marie Luisa Schmidt, Thomas Hoenen Background Ebola virus (EBOV) causes a severe hemorrhagic fever in humans and non-human primates. While no licensed therapeutics are available, recently there has been tremendous progress in developing antivirals. Targeting the ribonucleoprotein complex (RNP) proteins, which facilitate genome replication and transcription, and particularly the polymerase L, is a promising antiviral approach since these processes are essential for the virus life cycle


Application of a loop-mediated isothermal amplification (LAMP) assay targeting…

by S. M. Mazidur Rahman, Hyun Beom Song, Yan Jin, Jin-Kyoung Oh, Min Kyung Lim, Sung-Tae Hong, Min-Ho Choi Background Clonorchiasis is prevalent in the Far East, and a major health problem in endemic areas


Mitochondrial dual-coding genes in <i>Trypanosome brucei</i>

by Laura E. Kirby, Donna Koslowsky Trypanosoma brucei is transmitted between mammalian hosts by the tsetse fly. In the mammal, they are exclusively extracellular, continuously replicating within the bloodstream.


Health-related impact on quality of life and coping strategies for chikungunya: A qualitative…

by Jelte Elsinga, Martin P. Grobusch, Adriana Tami, Izzy Gerstenbluth, Ajay Bailey Introduction Chikungunya is an emerging public health problem in tropical and subtropical regions, due to ongoing transmission and its incapacitating acute disease phase, and chronic sequelae. The disease is responsible for a major impact on Health Related Quality of Life (HRQoL), which may last several years.


Next-generation ELISA diagnostic assay for Chagas Disease based on the combination of short…

by Juan Mucci, Santiago J. Carmona, Romina Volcovich, Jaime Altcheh, Estefanía Bracamonte, Jorge D. Marco, Morten Nielsen, Carlos A


Epidemiological consequences of immune sensitisation by pre-exposure to vector saliva

by Tsukushi Kamiya, Megan A. Greischar, Nicole Mideo Blood-feeding arthropods—like mosquitoes, sand flies, and ticks—transmit many diseases that impose serious public health and economic burdens.


Sanitation, hookworm, anemia, stunting, and wasting in primary school children in southern…

by Jack E. T.


How does competition among wild type mosquitoes influences the performance of <i>Aedes…

by Suellen de Oliveira, Daniel Antunes Maciel Villela, Fernando Braga Stehling Dias, Luciano Andrade Moreira, Rafael Maciel de Freitas Background Wolbachia has been deployed in several countries to reduce transmission of dengue, Zika and chikungunya viruses. During releases, Wolbachia-infected females are likely to lay their eggs in local available breeding sites, which might already be colonized by local Aedes sp. mosquitoes.


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