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Republican health plan seen as a major setback for hepatitis C Medicaid patients

Amid a growing hepatitis C epidemic, federal austerity measures seen as a setback to infection control.  By Sony Salzman It’s been nearly 20 years since Read More

Meet the amazing cast behind a life-changing drug

It was well after midnight in San Francisco when Eugenio (“Geno”) de Hostos picked up the phone—but when his colleagues in China answered, he felt the familiar jolt of excitement. He’d felt the same thrill at dawn, talking to his colleagues in Switzerland. At five, in a call to Maryland with the US Food and […] ; ; ; ;Related StoriesWaking from sleeping sickness in the DRCThe surprising consequences of tuberculosisPATH is at SXSW ;

Photo: PATH/Lynn Heinisch.

Lessons from the front lines

In the midst of the 2014 Ebola outbreak in West Africa, a 21-year-old Guinean student came to a Dakar health clinic with symptoms of fever and diarrhea. The doctor considered Ebola, which had killed more than 1,000 people in neighboring Guinea. But the patient wasn’t bleeding. He denied having been in contact with Ebola patients […] ; ; ; ;Related StoriesIn Davos, Rx for epidemics: tech partnershipsInnovation is at the heart of SeattleOur 8 favorite photos of 2016 ;

Latest

A new method for sequencing the hypervariable Plasmodium falciparum gene var2csa from clinical…

VAR2CSA, a member of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family, mediates the binding of P.


Evaluation of piperonyl butoxide in enhancing the efficacy of pyrethroid insecticides against…

Malaria vector control methods involving the use of pyrethroids remain the strategies being used against malaria vectors in Ghana.


Do the venous blood samples replicate malaria parasite densities found in capillary blood? A…

The measure of new drug- or vaccine-based approaches for malaria control is based on direct membrane feeding assays (DMFAs) where gametocyte-infected blood samples are offered to mosquitoes through an artifici…


Modelling the benefits of long-acting or transmission-blocking drugs for reducing Plasmodium…

Anti-malarial drugs are an important tool for malaria control and elimination.


Which intervention is better for malaria vector control: insecticide mixture long-lasting…

Malaria control today is threatened by widespread insecticide resistance in vector populations.


The development of an ivermectin-based attractive toxic sugar bait (ATSB) to target Anopheles…

An increasing number of countries in sub-Saharan Africa are moving towards malaria-elimination, mostly thanks to successful vector control campaigns.


Circulating microRNAs in malaria infection: bench to bedside

Severe malaria has a poor prognosis with a morbidity rate of 80% in tropical areas.


Adherence to ivermectin is more associated with perceptions of community directed treatment…

by Fanny Nadia Dissak-Delon, Guy-Roger Kamga, Perrine Claire Humblet, Annie Robert, Jacob Souopgui, Joseph Kamgno, Marie José Essi, Stephen Mbigha Ghogomu, Isabelle Godin Background The fight against onchocerciasis in Africa has boomed thanks to the Community Directed Treatment with Ivermectin (CDTI) program. However, in Cameroon, after more than 15 years of mass treatment, onchocerciasis prevalence is still above the non-transmission threshold. This study aimed to explore a possible association between people’s beliefs/perceptions of onchocerciasis and of CDTI program, and their adherence to ivermectin in three regions of Cameroon


An economic evaluation of vector control in the age of a dengue vaccine

by Christopher Fitzpatrick, Alexander Haines, Mathieu Bangert, Andrew Farlow, Janet Hemingway, Raman Velayudhan Introduction Dengue is a rapidly emerging vector-borne Neglected Tropical Disease, with a 30-fold increase in the number of cases reported since 1960. The economic cost of the illness is measured in the billions of dollars annually. Environmental change and unplanned urbanization are conspiring to raise the health and economic cost even further beyond the reach of health systems and households


Endothelial activation and dysfunction in severe fever with thrombocytopenia syndrome

by Xiao-Kun Li, Zhen-Dong Yang, Juan Du, Bo Xing, Ning Cui, Pan-He Zhang, Hao Li, Xiao-Ai Zhang, Qing-Bin Lu, Wei Liu Background Pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) has not been well described yet. Recent studies indicate that SFTSV could replicate in endothelial cells. Here we performed a case-control study to determine whether endothelial activation/dysfunction occurred in SFTSV infection and to identify the biomarkers reflecting endothelial dysfunction.


Asymptomatic and Sub-Microscopic Malaria: a Challenge to Elimination Efforts

WHO says that, “In settings where malaria is actively being eliminated or has been eliminated, a “case” is the occurrence of any confirmed malaria infection with or without symptoms.” Several recent studies describe the importance of paying attention to asymptomatic infections. In the Bagamoyo District of Tanzania Sumari and colleagues collected blood samples and examined them for Plasmodium falciparum prevalence using rapid diagnostic test (RDT), light microscopy (LM) and reverse transcription quantitative PCR. While overall prevalence was higher in symptomatic children using all three methods, asymptomatic children had a higher prevalence of gametocytes using light microscopy and PCR.  They concluded that, “The higher gametocytemia observed in asymptomatic children indicates the reservoir infections and points to the need for detection and treatment of both asymptomatic and symptomatic malaria.” The health effects of asymptomatic plasmodial infections (API) on children were documented in Rwanda. These included “Plasmodium infection was associated with anaemia, fever, underweight, clinically assessed malnutrition and histories of fever, tiredness, weakness, poor appetite, abdominal pain, and vomiting” and were generally more common with submicroscopic infection


Clinical and molecular surveillance of artemisinin resistant falciparum malaria in Myanmar…

Emergence of artemisinin-resistant malaria in Southeast Asian countries threatens the global control of malaria.


Artemisinin combination therapy mass drug administration in a setting of low malaria…

Mass drug administration (MDA) appears to be effective in reducing the risk of malaria parasitaemia.


The Trypomastigote Small Surface Antigen (TSSA) regulates <i>Trypanosoma cruzi</i>…

by María de los Milagros Cámara, Gaspar E. Cánepa, Andrés B. Lantos, Virginia Balouz, Hai Yu, Xi Chen, Oscar Campetella, Juan Mucci, Carlos A


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