Infectious Disease

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Are partnerships the key to making critical progress in Global Health?

When it comes to Global Health, there are a number of challenges that the global health community should be aware of and focused on. Many Read More

Republican health plan seen as a major setback for hepatitis C Medicaid patients

Amid a growing hepatitis C epidemic, federal austerity measures seen as a setback to infection control.  By Sony Salzman It’s been nearly 20 years since Read More

Meet the amazing cast behind a life-changing drug

It was well after midnight in San Francisco when Eugenio (“Geno”) de Hostos picked up the phone—but when his colleagues in China answered, he felt the familiar jolt of excitement. He’d felt the same thrill at dawn, talking to his colleagues in Switzerland. At five, in a call to Maryland with the US Food and […] ; ; ; ;Related StoriesWaking from sleeping sickness in the DRCThe surprising consequences of tuberculosisPATH is at SXSW ;

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Microexon gene transcriptional profiles and evolution provide insights into blood processing by…

by Xiao-Hong Li, Ricardo DeMarco, Leandro X. Neves, Sally R. James, Katherine Newling, Peter D


Vector-borne disease risk indexes in spatially structured populations

by Jorge Velázquez-Castro, Andrés Anzo-Hernández, Beatriz Bonilla-Capilla, Moisés Soto-Bajo, Andrés Fraguela-Collar There are economic and physical limitations when applying prevention and control strategies for urban vector borne diseases. Consequently, there are increasing concerns and interest in designing efficient strategies and regulations that health agencies can follow in order to reduce the imminent impact of viruses like Dengue, Zika and Chikungunya. That includes fumigation, abatization, reducing the hatcheries, picking up trash, information campaigns


Community knowledge, perceptions and attitudes regarding leprosy in rural Cameroon: The case of…

by Earnest Njih Tabah, Dickson Shey Nsagha, Anne-Cecile Zoung-Kanyi Bissek, Theophilus Ngeh Njamnshi, Irine Ngani-Nformi Njih, Gerd Pluschke, Alfred Kongnyu Njamnshi Background Although leprosy is one of the oldest diseases known to humanity, it remains largely misunderstood. Misconceptions about leprosy leads to stigma towards people with the disease.


The impact of insecticide applications on the dynamics of resistance: The case of four…

by Gabriela de Azambuja Garcia, Mariana Rocha David, Ademir de Jesus Martins, Rafael Maciel de Freitas, Jutta Gerlinde Birggitt Linss, Simone Costa Araújo, José Bento Pereira Lima, Denise Valle Background In the tropics, the utilization of insecticides is still an important strategy for controlling Aedes aegypti, the principle vector of dengue, chikungunya and Zika viruses. However, increasing insecticide resistance in Ae. aegypti populations might hinder insecticide efficacy on a long-term basis.


Endogenous overexpression of an active phosphorylated form of DNA polymerase β under oxidative…

by Diego A. Rojas, Fabiola Urbina, Sandra Moreira-Ramos, Christian Castillo, Ulrike Kemmerling, Michel Lapier, Juan Diego Maya, Aldo Solari, Edio Maldonado Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative stress, leading to damage of several macromolecules such as DNA. There are many DNA repair pathways in the nucleus and mitochondria (kinetoplast), where specific protein complexes detect and eliminate damage to DNA


The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in…

by Ravi Mehta, Cristiane Nascimento Soares, Raquel Medialdea-Carrera, Mark Ellul, Marcus Tulius Texeira da Silva, Anna Rosala-Hallas, Marcia Rodrigues Jardim, Girvan Burnside, Luciana Pamplona, Maneesh Bhojak, Radhika Manohar, Gabriel Amorelli Medeiros da Silva, Marcus Vinicius Adriano, Patricia Brasil, Rita Maria Ribeiro Nogueira, Carolina Cardoso Dos Santos, Lance Turtle, Patricia Carvalho de Sequeira, David W. Brown, Michael J. Griffiths, Ana Maria Bispo de Filippis, Tom Solomon Background During 2015–16 Brazil experienced the largest epidemic of Zika virus ever reported.


Clinical findings and prognosis of patients hospitalized for acute decompensated heart failure:…

by Caíque Bueno Terhoch, Henry Fukuda Moreira, Silvia Moreira Ayub-Ferreira, Germano Emilio Conceição-Souza, Vera Maria Cury Salemi, Paulo Roberto Chizzola, Mucio Tavares Oliveira Jr, Silvia Helena Gelas Lage, Edimar Alcides Bocchi, Victor Sarli Issa Aims Explore the association between clinical findings and prognosis in patients with acute decompensated heart failure (ADHF) and analyze the influence of etiology on clinical presentation and prognosis. Methods and results Prospective cohort of 500 patients admitted with ADHF from Aug/2013-Feb/2016; patients were predominantly male (61.8%), median age was 58 (IQ25-75% 47–66 years); etiology was dilated cardiomyopathy in 141 (28.2%), ischemic heart disease in 137 (27.4%), and Chagas heart disease in 113 (22.6%). Patients who died (154 [30.8%]) or underwent heart transplantation (53[10.6%]) were younger (56 years [IQ25-75% 45–64 vs 60 years, IQ25-75% 49–67], P = 0.032), more frequently admitted for cardiogenic shock (20.3% vs 6.8%, P<0.001), had longer duration of symptoms (14 days [IQ<sub>25-75% 4–32.8 vs 7.5 days, IQ25-75% 2–31], P = 0.004), had signs of congestion (90.8% vs 76.5%, P<0.001) and inadequate perfusion more frequently (45.9% vs 28%, <i>P<0.001), and had lower blood pressure (90 [IQ<sub>25-75% 80–100 vs 100, IQ25-75% 90–120], P<0.001)


<i>In vitro</i> studies of <i>Rickettsia</i>-host cell interactions:…

by Stephanie Speck, Tanja Kern, Karin Aistleitner, Meik Dilcher, Gerhard Dobler, Sandra Essbauer Rickettsia (R.) helvetica is the most prevalent rickettsia found in Ixodes ricinus ticks in Germany. Several studies reported antibodies against R.


Prevalence of trachoma in the Kayes region of Mali eight years after stopping mass drug…

by Lamine Traoré, Benoit Dembele, Modibo Keita, Steven Reid, Mahamadou Dembéle, Bréhima Mariko, Famolo Coulibaly, Whitney Goldman, Dramane Traoré, Daouda Coulibaly, Boubacar Guindo, Joe Amon, Marily Knieriemen, Yaobi Zhang Background In 2009, three years after stopping mass treatment with azithromycin, a trachoma impact survey in four health districts in the Kayes region of Mali found a prevalence of trachomatous inflammation—follicular (TF) among children aged 1 to 9 years of >5% and a trachomatous trichiasis (TT) prevalence within the general population (≥1-year-old) of <1%. As a result, the government’s national trachoma program expanded trichiasis surgery and related activities required to achieve trachoma elimination.</p> Methodology/Principal findings In 2015, to assess progress towards elimination, a follow-up impact survey was conducted in the Kayes, Kéniéba, Nioro and Yélimané health districts.


Diarrhea, the time thief

Diarrhea, the time thief hrandall Mon, 02/12/2018 – 10:56 Feb 12, 2018 Thomas Wierzba Senior Scientist, PATH’s Center for Vaccine Development and Access (CVIA) A child in Sudan receives ORS during a hospital stay for severe diarrhea. PATH/Doune Porter.   Global deaths from diarrhea are falling, rapidly. This is encouraging news—it means that fewer parents are living with the tragedy of a child lost to diarrhea.


Funding To Support CDC’s Frontline Outbreak Response Efforts Critical To Preventing,…

Washington Post: The next pandemic will come sooner or later. The CDC needs money to prepare. Editorial Board “…At the time of the Ebola crisis, Congress approved a one-time, five-year emergency supplemental spending package … Anticipating that that money will run out in October 2019, the CDC has begun notifying country directors to begin planning…More


3 Ways U.S. Should Prepare For Future Influenza Pandemic

The Conversation: 3 ways the U.S. should prepare for the next flu pandemic Lance Gable, associate professor at Wayne State University “…If the world were to face a new strain of flu similar in novelty and virulence to the 1918 virus, our capacity to prevent a pandemic would still fall short because we have not…More


Unique pharmacological properties of serotonergic G-protein coupled receptors from cestodes

by Federico Camicia, Ana M. Celentano, Malcolm E. Johns, John D.


A natural agonist of mosquito TRPA1 from the medicinal plant <i>Cinnamosma…

by Edna Alfaro Inocente, Marguerite Shaya, Nuris Acosta, L. Harinantenaina Rakotondraibe, Peter M. Piermarini Plants produce various secondary metabolites that offer a potential source of novel insecticides and repellents for the control of mosquito vectors


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