Vaccines

Featured

Cynthia GoldsmithThis colorized transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by an Ebola virus virion. See PHIL 1832 for a black and white version of this image.Where is Ebola virus found in nature?The exact origin, locations, and natural habitat (known as the "natural reservoir") of Ebola virus remain unknown. However, on the basis of available evidence and the nature of similar viruses, researchers believe that the virus is zoonotic (animal-borne) and is normally maintained in an animal host that is native to the African continent. A similar host is probably associated with Ebola-Reston which was isolated from infected cynomolgous monkeys that were imported to the United States and Italy from the Philippines. The virus is not known to be native to other continents, such as North America.

Ebola Vaccine Candidates: Phase 1 Trial Results (NEJM)

This week, preliminary results from two phase 1 trials were published in the New England Journal of Medicine. Overall, the trials demonstrated safety and the Read More

Image pmed.1001403.blog_.jpg

U.S. Must Increase Capacity For Global Health R&D, Anticipate Global Disease Threats

Washington Post: Why aren’t we producing medications for looming global disease threats? Mel Spigelman, physician and president and chief executive of TB Alliance “…[A new Global Health Technologies Coalition] analysis reveals that over the past six years, [U.S.] taxpayer funding for global health research has been stagnant or declining. … Managing health threats through emergency…More

no image

Working Towards an Achievable Goal: A World without CRS

Susan Reef, MD, Rubella Team Lead, Global Immunization Division When I started focusing on rubella in 1994, it was mainly recognized as a significant public health problem in high-income countries. When the public health community realized that rubella and congenital rubella syndrome (CRS) were actually significant public health issues in the entire region of the Americas, things took a turn and an elimination goal was set for 2010. In the pre-vaccine era, some 20,000 infants were born each year in the Americas region with CRS and one or more of its devastating birth defects. I look at our success in achieving the elimination goal —which occurred in 2009, a year before the target date—in terms of the lives it impacted: 20,000 of them, born free of CRS disabilities each year since then.

Latest

Vaccinations Essential To Protecting Health, Well-Being Of Children In India

Huffington Post: Giving Our Children A Shot At Health Vishwajeet Kumaar, scientist and founder and CEO of Community Empowerment Lab “This World Immunization Week (April 24-30), countries around the world will celebrate one of the most transformative health interventions in the history of public health — vaccines. … Last month, the government [of India] launched…More


Providing HPV Vaccine To Women Worldwide Vital To Preventing Cervical Cancer Cases, Deaths

Project Syndicate: Stopping Women’s Next Biggest Killer Anuradha Gupta, deputy CEO of Gavi, the Vaccine Alliance “…For the first time, the number of deaths caused by cervical cancer every year is poised to outstrip the total caused by childbirth. … The tragedy is that these deaths are almost entirely preventable. Human papillomavirus (HPV) vaccines, coupled…More


WHO Calls For Disclosure Of All Clinical Trial Results, In Effort To Increase Transparency,…

Reuters: WHO demands disclosure of all clinical trial results “The World Health Organization called on Tuesday for the release of clinical trial results for all drugs, vaccines, and medical devices — whatever the result — in the latest salvo against the withholding of data…” (4/14). World Health Organization: WHO calls for increased transparency in medical…More


Guinea Ebola Vaccine Clinical Trial Holds Best Hope For Useful Data Amid Shrinking Epidemic,…

Reuters: Completing Ebola vaccine trials ‘a challenge’ as epidemic wanes “Falling Ebola cases in West Africa make completing big clinical trials on experimental vaccines a challenge, with the best hope resting on a study in Guinea, the World Health Organization said on Friday. While the waning epidemic is good news for long-suffering populations in the…More


Questions Remain Over Ebola Vaccine Trials As Epidemic Subsides

Wall Street Journal: Squabbles Over Testing Methods Hamper Search for Ebola Vaccine “The Ebola virus outbreak in West Africa created a rare opportunity: New vaccines could be tested, and if they worked, serve as a firewall in future epidemics. It now appears this chance is slipping away amid public health officials’ squabbles over the right…More


2 Experimental Ebola Vaccines Show Promise In Primate Trials

CIDRAP News: Second-generation Ebola vaccines show promise in animal study “Two candidate Ebola vaccines developed as possible next-generation products fully protected monkeys immunized with a single dose against experimental infection with the strain responsible for West Africa’s outbreak, researchers reported [Wednesday]…” (Schnirring, 4/8). New York Times: 2 New Ebola Vaccines Pass Important Early Test, Researchers…More


International Community Has Taken Major Strides Toward Eradicating Polio Since Salk Vaccine…

Pittsburgh Post-Gazette: Sixty years later, recalling the Jonas Salk polio ‘miracle’ “Sixty years ago this coming Sunday, the Salk polio vaccine was declared ‘safe, effective, and potent,’ an announcement cheered with the fervor of a national holiday. … While there are still three countries where transmission of polio has never been interrupted — Nigeria, Pakistan…More


Less U.S. R&D Funding, Vaccine Opposition Highlight Dangers To Global Health Progress, Reports…

SciDev.Net: Budget cuts and vaccine fears threaten health progress “Cuts to global health research budgets and people’s wariness of vaccines could hamper efforts to improve health around the world, two separate reports have warned in the run-up to World Health Day, which is marked [April 7]. One of the reports, published by the Global Health…More


Pfizer Ceases Sale Of Children’s Vaccine In China

Agence France-Presse: Pfizer stops sale of children’s vaccine in China “American pharmaceutical giant Pfizer has stopped selling one of its lucrative vaccines for children in China, the company said. Pfizer gave no explanation for stopping its sales of the Prevnar vaccine, which helps prevent infections such as pneumonia, which killed an estimated 935,000 children under…More


Lessons Learned From Ebola Outbreak Demonstrate Importance Of Vaccine Research, Development

Center for Global Health Policy’s “Science Speaks”: Lessons from Ebola: A vaccine fast track too slow demonstrates need to prepare for pandemic potential diseases Elizabeth Bukowski, freelance journalist and veterinarian, reports from the 3rd International One Health Congress in Amsterdam and discusses comments from the director of the Jenner Institute at Oxford University, Adrian Hill,…More


Ebola Vaccine Candidates: Phase 1 Trial Results (NEJM)

Cynthia GoldsmithThis colorized transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by an Ebola virus virion. See PHIL 1832 for a black and white version of this image.Where is Ebola virus found in nature?The exact origin, locations, and natural habitat (known as the "natural reservoir") of Ebola virus remain unknown. However, on the basis of available evidence and the nature of similar viruses, researchers believe that the virus is zoonotic (animal-borne) and is normally maintained in an animal host that is native to the African continent. A similar host is probably associated with Ebola-Reston which was isolated from infected cynomolgous monkeys that were imported to the United States and Italy from the Philippines. The virus is not known to be native to other continents, such as North America.

This week, preliminary results from two phase 1 trials were published in the New England Journal of Medicine. Overall, the trials demonstrated safety and the Read More


Ebola Vaccine Trials Show Promise, Scientists Say

VOA News: Ebola Vaccine Trials Underway in West Africa “…Since last summer, researchers have rushed to get anti-Ebola vaccines into clinical trials. While it’s too early to say that any of the potential vaccines work, some scientists say they are seeing strong results from some of the studies…” (Pearson, 3/30).


NIH Confirms Safety Of 2 Experimental Ebola Vaccines

Reuters: Two experimental Ebola vaccines pass safety test in African trial “Two experimental Ebola vaccines, one from GlaxoSmithKline PLC and the other from biotech start-up NewLink Genetics Corp, ‘appear to be safe’ part way through a clinical trial being conducted in Liberia, the U.S. National Institutes of Health (NIH) said on Thursday…” (Begley, 3/26). Wall…More


U.S. Must Increase Capacity For Global Health R&D, Anticipate Global Disease Threats

Image pmed.1001403.blog_.jpg

Washington Post: Why aren’t we producing medications for looming global disease threats? Mel Spigelman, physician and president and chief executive of TB Alliance “…[A new Global Health Technologies Coalition] analysis reveals that over the past six years, [U.S.] taxpayer funding for global health research has been stagnant or declining. … Managing health threats through emergency…More


Older Posts »