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New data, editorials and podcasts on Malaria @NEJM

The July 31st issue of the New England Journal has several new pieces on Malaria – ranging from original articles on “Artemisinin Resistance in P. falciparum” Read More

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How to reach every newborn: three key messages

The Every Newborn Action Plan (ENAP) launched on June 30–July 1, 2014, envisages a world without preventable deaths of newborn infants. The challenge is not technical (effective interventions exist), but instead social. The odds of a child surviving the first month of life are grossly unequal, even within one country, and are affected by wealth, education, caste, and access to health care. Large gains are achievable when interventions reach people who are in need, but this rarely occurs. Without dedicated efforts to reach poor people, ENAP initiatives are likely to favour wealthier people who have the lowest mortality risk.

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#Post2015 health goals: could country-specific targets supplement global ones?

Although Millennium Development Goals 4, 5, and 6 have helped mobilise global action to improve health, many sub-Saharan African countries will not come close to Read More

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Characteristics of B-Cell Lymphomas in HIV/HCV-Coinfected Patients

No abstract available


Comment on “Characteristics of B-Cell Lymphomas in HIV/HCV-Coinfected Patients During the…

No abstract available


Ebola: a blind outbreak

Grazia Caleo of Médecins Sans Frontières (MSF) UK describes her experiences as a medical epidemiologist during the Ebola outbreak in Kailhun, Sierra Leone. In José Saramago’s book, Blindness, he describes an epidemic of an unknown infection that causes people to …The post Ebola: a blind outbreak appeared first on Speaking of Medicine.


Sporotrichosis in Rio de Janeiro, Brazil: Sporothrix brasiliensis Is Associated with Atypical…

by Rodrigo Almeida-Paes, Manoel Marques Evangelista de Oliveira, Dayvison Francis Saraiva Freitas, Antônio Carlos Francesconi do Valle, Rosely Maria Zancopé-Oliveira, Maria Clara Gutierrez-Galhardo Background There have been several recent changes in the taxonomy of Sporothrix schenckii as well as new observations regarding the clinical aspects of sporotrichosis. In this study, we determined the identification of the Sporothrix species associated with both classic and unusual clinical aspects of sporotrichosis observed in the endemic area of sporotrichosis in Rio de Janeiro, Brazil. Methodology/Principal Findings To verify whether S.


NLRC4 and TLR5 Each Contribute to Host Defense in Respiratory Melioidosis

by T. Eoin West, Nicolle D. Myers, Narisara Chantratita, Wirongrong Chierakul, Direk Limmathurotsakul, Vanaporn Wuthiekanun, Edward A.


Status of Onchocerciasis Transmission after More Than a Decade of Mass Drug Administration for…

by Darin S. Evans, Kal Alphonsus, Jon Umaru, Abel Eigege, Emmanuel Miri, Hayward Mafuyai, Carlos Gonzales-Peralta, William Adamani, Elias Pede, Christopher Umbugadu, Yisa Saka, Bridget Okoeguale, Frank O. Richards Background This study was undertaken in five onchocerciasis/lymphatic filariasis (LF) co-endemic local government areas (LGAs) in Plateau and Nasarawa, Nigeria


Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli

by Patrícia Hermes Stoco, Glauber Wagner, Carlos Talavera-Lopez, Alexandra Gerber, Arnaldo Zaha, Claudia Elizabeth Thompson, Daniella Castanheira Bartholomeu, Débora Denardin Lückemeyer, Diana Bahia, Elgion Loreto, Elisa Beatriz Prestes, Fábio Mitsuo Lima, Gabriela Rodrigues-Luiz, Gustavo Adolfo Vallejo, José Franco da Silveira Filho, Sérgio Schenkman, Karina Mariante Monteiro, Kevin Morris Tyler, Luiz Gonzaga Paula de Almeida, Mauro Freitas Ortiz, Miguel Angel Chiurillo, Milene Höehr de Moraes, Oberdan de Lima Cunha, Rondon Mendonça-Neto, Rosane Silva, Santuza Maria Ribeiro Teixeira, Silvane Maria Fonseca Murta, Thais Cristine Marques Sincero, Tiago Antonio de Oliveira Mendes, Turán Peter Urmenyi, Viviane Grazielle Silva, Wanderson Duarte DaRocha, Björn Andersson, Álvaro José Romanha, Mário Steindel, Ana Tereza Ribeiro de Vasconcelos, Edmundo Carlos Grisard Background Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans and other wild and domestic mammals across Central and South America. It does not cause human disease, but it can be mistaken for the etiologic agent of Chagas disease, Trypanosoma cruzi. We have sequenced the T.


Visceral Leishmaniasis and HIV Coinfection in Latin America

by José Angelo Lindoso, Gláucia Fernandes Cota, Alda Maria da Cruz, Hiro Goto, Ana Nilce Silveira Maia-Elkhoury, Gustavo Adolfo Sierra Romero, Márcia Leite de Sousa-Gomes, Joanna Reis Santos-Oliveira, Ana Rabello Visceral leishmaniasis (VL) is an endemic zoonotic disease in Latin America caused by Leishmania (Leishmania) infantum, which is transmitted by sand flies from the genus Lutzomyia. VL occurs in 12 countries of Latin America, with 96% of cases reported in Brazil. Recently, an increase in VL, primarily affecting children and young adults, has been observed in urban areas of Latin America


Extracellular Vesicles from Leishmania-Infected Macrophages Confer an Anti-infection…

by André Cronemberger-Andrade, Luciana Aragão-França, Cintia Figueiredo de Araujo, Viviane Junqueira Rocha, Mariana da Cruz Borges-Silva, Cláudio P. Figueiras, Pablo R.


In Honor of Dr. Elisabetta Ullu

Kasturi Haldar, PLOS Pathogens Editor-in-Chief, reflects on Elisabetta Ullu’s pioneering contributions to the understanding of molecular mechanisms of RNAi in T. brucei. On the eve of 25th anniversary of the premier Molecular Parasitology Meeting (MPM) held at the …The post In Honor of Dr. Elisabetta Ullu appeared first on Speaking of Medicine.


Low immigrant mortality in England and Wales: A data artefact?

Publication date: November 2014 Source:Social Science & Medicine, Volume 120 Author(s): Matthew Wallace , Hill Kulu Previous research shows low mortality for most immigrants compared to natives in host countries.


The unfinished body: The medical and social reshaping of disabled young bodies

Publication date: November 2014 Source:Social Science & Medicine, Volume 120 Author(s): Janice McLaughlin , Edmund Coleman-Fountain Stories about disability are heavily shaped by the narratives offered by medicine and society.


Cost-Effectiveness of Socioeconomic Support as Part of HIV Care for the Poor in an Urban…

Background: Socioeconomic support reduced nonretention in a community-based antiretroviral therapy (ART) program in Uganda.


Mortality Among Adults Transferred and Lost to Follow-up From Antiretroviral Therapy Programmes…

Background and Objectives: Little is known about outcomes after transfer out (TFO) and loss to follow-up (LTF) and how differential outcomes might bias mortality estimates, as analyses generally censor or exclude TFOs/LTF.


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