Tag Archives: drug development

World No Tobacco Day – except to make malaria drugs

May 31st marks World No Tobacco Day. The Theme for 2017 is “Tobacco – a threat to development.” According to WHO, “Tobacco control has been enshrined in the Sustainable Development Agenda. It is seen as one of the most effective means to help achieve SDG target 3.4 of a one-third reduction globally, by 2030, of premature deaths from  noncommunicable diseases (NCDs).” Control is also associated with positive environmental and anti-poverty outcomes. It is ironic then that the tobacco plant itself may be modified to produce life saving anti-malarial medicines.

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Development of in-vitro screening assay for anti-tapeworm drugs

by Dominic Ritler, Reto Rufener, Heinz Sager, Jacques Bouvier, Andrew Hemphill, Britta Lundström-Stadelmann Intestinal cestodes are infecting millions of people and livestock worldwide, but treatment is mainly based on one drug: praziquantel. The identification of new anti-cestodal compounds is hampered by the lack of suitable screening assays. It is difficult, or even impossible, to evaluate drugs against adult cestodes in vitro due to the fact that these parasites cannot be cultured in microwell plates, and adult and larval stages in most cases represent different organisms in terms of size, morphology, and metabolic requirements.

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Drugs for Malaria: the Challenge of Resistance to Front Line Therapy in Control and Elimination

In honor of World Malaria Day, Kasturi Haldar, Editor-in-Chief of PLOS Pathogens comments on the challenge of resistance to frontline drugs in malaria treatment, control, and elimination on the path to eradication.  From 2010-2015 new

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Meet the amazing cast behind a life-changing drug

It was well after midnight in San Francisco when Eugenio (“Geno”) de Hostos picked up the phone—but when his colleagues in China answered, he felt the familiar jolt of excitement. He’d felt the same thrill at dawn, talking to his colleagues in Switzerland. At five, in a call to Maryland with the US Food and […] ; ; ; ;Related StoriesWaking from sleeping sickness in the DRCThe surprising consequences of tuberculosisPATH is at SXSW ;

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The surprising consequences of tuberculosis

Tuberculosis, a disease with history In the 1990s, following the collapse of the Soviet Union, Ukraine experienced serious medication delivery delays. For patients with tuberculosis (TB), the lack of medications resulted in incomplete drug regimens and poor treatment practices. Although the drug supply problem resolved over time, a new challenge arose: Ukraine became one of […] ; ; ; ;Related StoriesWaking from sleeping sickness in the DRCLes leçons de la ligne de frontUp to the challenge: a doctor’s story of sacrifice and healing ;

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Waking from sleeping sickness in the DRC

Marthine clearly loves Octavie. Even now, when his wife of 48 years moves like a sleepwalker, he dotes on her. He encourages her to eat the food he’s brought to the hospital and adjusts her clothes to protect her dignity. When she emerges from her lethargy to muster a smile, he beams. Octavie has sleeping […] ; ; ; ;Related StoriesLes leçons de la ligne de frontUp to the challenge: a doctor’s story of sacrifice and healingLessons from the front lines ;

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PATH is at SXSW

PATH is headed to SXSW! David Shoultz, the head of our Drug Development Program, will join other panelists from the Bill & Melinda Gates Foundation and John Snow, Inc. to discuss the benefits and challenges of tech solutions in developing regions around the world. While in Austin, a small field team and I will be […] ; ; ; ;Related StoriesInnovation is at the heart of SeattlePATH: 40 years of innovation and impactWANTED: idealistic students to save millions of lives ;

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WANTED: idealistic students to save millions of lives

Conventional wisdom about STEM education in the United States goes something like this: we need to do a better job teaching our students math and science so they can fill a mind-boggling number of high-paying jobs in the tech sector, which are fueling our economy. That’s certainly part of the story. But if we view […] ; ; ; ;Related StoriesInnovation is at the heart of SeattlePATH: 40 years of innovation and impactIn Davos, Rx for epidemics: tech partnerships ;

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PrEP sẽ có mặt tại Việt Nam?

Bảo Ân, một lãnh đạo cộng đồng đồng tính nam, đồng thời là nhân viên của tổ chức PATH chia sẻ: “Những người đồng tính nam và chuyển giới nữ tại TPHồ Chí Minh –đô thị lớn nhất của Việt Nam đang bị ảnh hưởng nặng nề bởiHIV”. Anh cho biết: “Do những can thiệp […] ; ; ; ;Related StoriesIs Vietnam prepared for PrEP?The politics of pneumoniaWhy playtime for babies is serious business ;

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Is Vietnam prepared for PrEP?

Bao An, a leader in the gay community and PATH staff member, is concerned. “Gay men and transgender women,” Bao An says, “are disproportionately affected by HIV in Ho Chi Minh City, the largest urban area in Vietnam.” He adds that because HIV interventions for these populations were developed later in the epidemic, many people […] ; ; ; ;Related StoriesYou have the right to liveThe politics of pneumoniaHIV positive and living positively ;

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You have the right to live

When you’re 12 and a girl, sharing your HIV diagnosis can be terrifying. Nanou couldn’t bring herself to tell her own father. For a long time, Nanou, who lives in the Democratic Republic of the Congo (DRC), fell sick practically every month. “My father thought I had malaria,” she says. Her mother had died from […] ; ; ; ;Related StoriesWhat does the US election mean for global health?The politics of pneumoniaOxygen is a matter of life and breath ;

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Why markets should matter to health advocates

Today, one of global health’s biggest challenges—and opportunities—lies in strengthening the markets that make health products, services, and technologies available to those who need them most. New global goals challenge us to work together to improve the health of all people by 2030. But we won’t reach those ambitious targets—and most importantly, save the lives […] ; ; ; ;Related StoriesWhat does the US election mean for global health?The politics of pneumoniaOxygen is a matter of life and breath ;

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Friday Think: Could the next big idea in global health be a list?

A quick swab of the mouth or prick of the finger. In just a few minutes, a doctor can tell if a patient has an infection or if the sample must be sent to a lab to deliver results within days. It’s a routine occurrence in doctors’ offices across high-income countries every day. But in […] ; ; ; ;Related StoriesWhat does the US election mean for global health?The politics of pneumoniaOxygen is a matter of life and breath ;

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What does the US election mean for global health?

After the initial shock of the 2016 election outcome, Washington, DC, is now in the throes of its new favorite sport: political armchair quarterbacking about what the new Administration and Congress will mean for various policy agendas. For those of us working in global health and development—and unlike in previous presidential transitions—little has been articulated […] ; ; ; ;Related StoriesThe politics of pneumoniaOxygen is a matter of life and breathDelivering new traditions for greater health ;

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